2E0G

DnaA N-terminal domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DnaA N-terminal domain-like	8046810	4005309	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RbfA-like	8090861	3000809	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF11638	e2e0gA2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ribosome-binding factor A (RbfA)-related (From Topology)	T: Ribosome-binding factor A (RbfA)-related	F: PF11638	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.300.180	Alpha Beta	2-Layer Sandwich	GMP Synthetase	Chain A, domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF11638	DnaA N-terminal domain (DnaA_N)	DnaA N-terminal domain	This family of proteins represents the N-terminal domain of DnaA, a protein involved in the initiation of bacterial chromosomal replication. The structure of this domain is known [1]. It is also found in three copies in some proteins such as Swiss:B5 ...	This family of proteins represents the N-terminal domain of DnaA, a protein involved in the initiation of bacterial chromosomal replication. The structure of this domain is known [1]. It is also found in three copies in some proteins such as Swiss:B5V0X4. The exact function of this domain is uncertain but it has been suggested to play a role in oligomerisation.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Chromosomal replication initiator protein dnaA	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA-templated DNA replication DNA replication initiation regulation of biological process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA-templated DNA replication DNA replication initiation regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process regulation of DNA-templated DNA replication initiation positive regulation of DNA replication positive regulation of biological process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of DNA metabolic process regulation of DNA-templated DNA replication positive regulation of DNA-templated DNA replication positive regulation of DNA-templated DNA replication initiation negative regulation of biological process negative regulation of DNA-templated DNA replication initiation negative regulation of DNA-templated DNA replication negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA replication negative regulation of metabolic process negative regulation of DNA metabolic process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular process cellular component organization or biogenesis	protein-containing complex intracellular anatomical structure protein-DNA complex chromosome cellular anatomical entity replication inhibiting complex intracellular organelle organelle DnaA-L2 complex intracellular non-membrane-bounded organelle replication fork replisome non-membrane-bounded organelle primosome complex protein-containing complex intracellular anatomical structure protein-DNA complex chromosome cellular anatomical entity replication inhibiting complex intracellular organelle organelle DnaA-L2 complex intracellular non-membrane-bounded organelle replication fork replisome non-membrane-bounded organelle primosome complex DnaA-HU complex cytoplasm cytosol cell periphery plasma membrane membrane DnaA-oriC complex DnaA-Dps complex cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane DnaA-DiaA complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR024633	DnaA N-terminal domain	Domain
A	IPR001957	Chromosomal replication control, initiator DnaA	Family
A	IPR013317	Chromosomal replication initiator protein DnaA	Domain
A	IPR003593	AAA+ ATPase domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR038454	DnaA, N-terminal domain superfamily	Homologous Superfamily
A	IPR018312	Chromosomal replication control, initiator DnaA, conserved site	Conserved Site
A	IPR013159	Chromosomal replication initiator, DnaA C-terminal	Domain
A	IPR020591	Chromosomal replication control, initiator DnaA-like	Family
A	IPR010921	Trp repressor/replication initiator	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.