Annotations: 6VEJ

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00873	e6vejA5	A: alpha bundles	X: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	T: Multidrug efflux transporter AcrB transmembrane domain	F: PF00873	ECOD (1.6)
A	F_UNCLASSIFIED	e6vejA6	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00873	e6vejA4	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: PF00873	ECOD (1.6)
A	F_UNCLASSIFIED	e6vejA2	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00873	e6vejA3	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: PF00873	ECOD (1.6)
B	PF00873	e6vejB8	A: alpha bundles	X: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	T: Multidrug efflux transporter AcrB transmembrane domain	F: PF00873	ECOD (1.6)
B	F_UNCLASSIFIED	e6vejB4	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00873	e6vejB1	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: PF00873	ECOD (1.6)
B	F_UNCLASSIFIED	e6vejB2	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00873	e6vejB6	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: PF00873	ECOD (1.6)
C	PF00873	e6vejC4	A: alpha bundles	X: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	T: Multidrug efflux transporter AcrB transmembrane domain	F: PF00873	ECOD (1.6)
C	F_UNCLASSIFIED	e6vejC5	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF00873	e6vejC1	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: PF00873	ECOD (1.6)
C	F_UNCLASSIFIED	e6vejC2	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF00873	e6vejC6	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: PF00873	ECOD (1.6)
D [auth P]	F_UNCLASSIFIED	e6vejP2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: F_UNCLASSIFIED	ECOD (1.6)

AMR Gene: CARD Annotation CARD Database Homepage

Chains	Accession	Short Name	Description	Provenance Source (Version)
A, B, C	ARO:3003681	TriC	TriC is a resistance nodulation cell division (RND) transporter that is a part of TriABC-OpmH, a triclosan-specific efflux protein.	CARD (3.2.9)
D [auth P], E [auth Q], F [auth R]	ARO:3003679	TriA	TriA is a membrane protein that is fused to TriB and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa.	CARD (3.2.9)

AMR Gene Family: CARD Annotation CARD Database Homepage

Chains	Accession	Gene Family	Drug Class	Resistance Machanism	Provenance Source (Version)
A, B, C	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	disinfecting agents and antiseptics	antibiotic efflux	CARD (3.2.9)
A, B, C	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	disinfecting agents and antiseptics	antibiotic efflux	CARD (3.2.9)
D [auth P], E [auth Q], F [auth R]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	disinfecting agents and antiseptics	antibiotic efflux	CARD (3.2.9)
D [auth P], E [auth Q], F [auth R]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	disinfecting agents and antiseptics	antibiotic efflux	CARD (3.2.9)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00873	AcrB/AcrD/AcrF family (ACR_tran)	AcrB/AcrD/AcrF family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Probable Resistance-Nodulation-Cell Division (RND) efflux transporter	xenobiotic transmembrane transporter activity transporter activity transmembrane transporter activity	-	cell periphery plasma membrane membrane cellular anatomical entity
D [auth P], E [auth Q], F [auth R]	Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein,Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein	efflux transmembrane transporter activity transporter activity transmembrane transporter activity	-	protein-containing complex efflux pump complex transmembrane transporter complex membrane membrane protein complex cellular anatomical entity transporter complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR001036	Acriflavin resistance protein	Family
A, B, C	IPR027463	Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains	Homologous Superfamily
D [auth P], E [auth Q], F [auth R]	IPR006143	RND efflux pump, membrane fusion protein	Family
D [auth P], E [auth Q], F [auth R]	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain	Domain
D [auth P], E [auth Q], F [auth R]	IPR006143	RND efflux pump, membrane fusion protein	Family
D [auth P], E [auth Q], F [auth R]	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM	Transmembrane	Alpha-helical polytopic	Resistance-nodulation-cell division	Hydrophobe/amphiphile efflux-1 family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Multi-Drug Efflux Transporters	TriABC Triclosan Efflux Pump

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.