Annotations: 6TUB

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF08035	Opioids neuropeptide (Op_neuropeptide)	Opioids neuropeptide	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Beta-endorphin	protein binding binding signaling receptor binding melanocortin receptor binding G protein-coupled receptor binding neuropeptide receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding hormone activity molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity protein binding binding signaling receptor binding melanocortin receptor binding G protein-coupled receptor binding neuropeptide receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding hormone activity molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway multicellular organismal process system process circulatory system process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway multicellular organismal process system process circulatory system process regulation of blood pressure regulation of biological quality blood circulation regulation of tumor necrosis factor production cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of tumor necrosis factor production organic substance metabolic process cytokine production organic substance biosynthetic process regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process negative regulation of metabolic process tumor necrosis factor superfamily cytokine production regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process regulation of localization corticosterone secretion regulation of system process regulation of glucocorticoid secretion localization regulation of steroid hormone secretion regulation of hormone levels organic substance transport lipid transport regulation of corticosteroid hormone secretion establishment of localization regulation of secretion endocrine hormone secretion lipid export from cell glucocorticoid secretion regulation of endocrine process corticosteroid hormone secretion regulation of corticosterone secretion regulation of hormone secretion transport steroid hormone secretion regulation of lipid transport organic hydroxy compound transport hormone secretion secretion by cell regulation of secretion by cell signal release regulation of signaling secretion regulation of transport lipid localization export from cell cell-cell signaling endocrine process regulation of lipid localization macromolecule localization hormone transport regulation of cell communication energy derivation by oxidation of organic compounds regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process regulation of primary metabolic process glucan metabolic process polysaccharide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process glycogen metabolic process primary metabolic process generation of precursor metabolites and energy energy reserve metabolic process regulation of glycogen metabolic process positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus cAMP-mediated signaling regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process positive regulation of intracellular signal transduction positive regulation of cAMP-mediated signaling regulation of response to stimulus regulation of cAMP-mediated signaling positive regulation of signaling calcium-mediated signaling pigmentation cellular pigmentation response to nutrient levels regulation of appetite response to organic substance response to hormone response to chemical response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to oxygen-containing compound response to nitrogen compound response to melanocyte-stimulating hormone oxytocin production positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of oxytocin production positive regulation of gene expression positive regulation of oxytocin production positive regulation of cellular biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis	membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle extracellular region membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle extracellular region vesicle lumen membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular organelle lumen organelle lumen extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR013531	Pro-opiomelanocortin/corticotropin, ACTH, central region	Domain
A, B, C, D, E A, B, C, D, E, F	IPR013532	Opiodes neuropeptide	Domain
A, B, C, D, E A, B, C, D, E, F	IPR013593	Pro-opiomelanocortin N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR001941	Pro-opiomelanocortin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P01189	obesity disorder obesity due to pro-opiomelanocortin deficiency ACTH-dependent Cushing syndrome sick sinus syndrome nephrocalcinosis hypertensive disorder renal cell carcinoma synovitis early myoclonic encephalopathy hypertrophic cardiomyopathy diabetes insipidus myasthenia gravis glomerulonephritis potassium deficiency disease long QT syndrome obesity disorder obesity due to pro-opiomelanocortin deficiency ACTH-dependent Cushing syndrome sick sinus syndrome nephrocalcinosis hypertensive disorder renal cell carcinoma synovitis early myoclonic encephalopathy hypertrophic cardiomyopathy diabetes insipidus myasthenia gravis glomerulonephritis potassium deficiency disease long QT syndrome cardiomyopathy melanoma fatty liver disease osteoporosis diabetes mellitus sarcomatoid renal cell carcinoma monogenic obesity chondrocalcinosis Pain multiple sclerosis cocaine abuse gout visual epilepsy collecting duct carcinoma ectopic ACTH secretion syndrome bipolar disorder epilepsy spastic quadriplegia proteinuria subvalvular aortic stenosis facial paralysis chromophobe renal cell carcinoma dissociative amnesia cocaine dependence congestive heart failure penile disease epilepsy with generalized tonic-clonic seizures pneumonia calcinosis acute kidney tubular necrosis cystitis melancholia restless legs syndrome opsoclonus-myoclonus syndrome cholestasis papillary renal cell carcinoma endogenous depression West syndrome heroin dependence kidney disease spastic monoplegia hyperaldosteronism acute liver failure eye disease substance withdrawal syndrome Cushing syndrome adrenal cortex disease cerebral palsy rhabdomyoma hypotensive disorder athetoid cerebral palsy autism urinary tract infection Dravet syndrome pancreas disease heart failure inherited lipid metabolism disorder sleep-wake disorder breast carcinoma constipation disorder pituitary cancer acquired metabolic disease spastic cerebral palsy acute kidney failure Addison disease cutaneous melanoma alcohol abuse hypoglycemia familial infantile myoclonic epilepsy hypopituitarism developmental and epileptic encephalopathy anxiety disorder hypothyroidism type 2 diabetes mellitus pain agnosia immune system disease inborn carbohydrate metabolic disorder myocardial ischemia intracerebral hemorrhage X-linked adrenal hypoplasia congenita acromegaly spastic diplegia coronary artery disease cancer hyperglycemia Cushing disease due to pituitary adenoma psychiatric disorder adenoma malignant glioma hypogonadism depressive disorder amnestic disorder mixed cerebral palsy digestive system disease mood disorder clear cell renal carcinoma eating disorder pituitary apoplexy acquired hyperprolactinemia Spasmus nutans burn pneumonitis Nelson syndrome neurotic disorder renal carcinoma amenorrhea familial avascular necrosis of femoral head

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.