Annotations: 6IRR

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00170	bZIP transcription factor (bZIP_1)	bZIP transcription factor	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Disrupted in schizophrenia 1 homolog,Cyclic AMP-dependent transcription factor ATF-4	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding protein binding transcription factor binding general transcription initiation factor binding cAMP response element binding protein binding DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein dimerization activity kinase binding enzyme binding protein kinase binding LRR domain binding protein domain specific binding leucine zipper domain binding molecular adaptor activity cytoskeletal protein binding kinesin binding	cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to manganese-induced endoplasmic reticulum stress response to stimulus cellular response to manganese ion cellular response to chemical stress response to inorganic substance cellular response to chemical stimulus cellular response to stress response to metal ion response to stress response to chemical cellular process cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to manganese-induced endoplasmic reticulum stress response to stimulus cellular response to manganese ion cellular response to chemical stress response to inorganic substance cellular response to chemical stimulus cellular response to stress response to metal ion response to stress response to chemical cellular process response to manganese ion response to endoplasmic reticulum stress developmental process multicellular organismal process ossification bone mineralization animal organ development anatomical structure development biomineral tissue development tissue development regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cellular response to nutrient levels response to nutrient levels response to starvation cellular response to glucose starvation cellular response to starvation response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus neuron apoptotic process positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process positive regulation of neuron apoptotic process programmed cell death regulation of neuron apoptotic process signaling cell-cell signaling gamma-aminobutyric acid signaling pathway cell communication inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis response to toxic substance response to oxidative stress cellular response to oxidative stress rhythmic process circadian regulation of gene expression circadian rhythm cellular developmental process hemopoiesis cell development embryo development multicellular organism development embryonic hemopoiesis cell differentiation embryonic organ development RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription sensory organ development visual system development cell morphogenesis epithelial cell differentiation eye morphogenesis lens morphogenesis in camera-type eye animal organ morphogenesis sensory system development system development camera-type eye morphogenesis lens fiber cell morphogenesis epithelium development eye development lens fiber cell development anatomical structure morphogenesis epithelial cell development sensory organ morphogenesis camera-type eye development lens fiber cell differentiation lens development in camera-type eye mRNA transcription by RNA polymerase II mRNA transcription transcription by RNA polymerase II mRNA metabolic process monosaccharide metabolic process carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process gluconeogenesis hexose biosynthetic process small molecule metabolic process glucose metabolic process organonitrogen compound metabolic process oxoacid metabolic process aspartate family amino acid metabolic process carboxylic acid metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process asparagine metabolic process L-asparagine metabolic process amide metabolic process intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of neuron apoptotic process negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction regulation of intrinsic apoptotic signaling pathway intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction negative regulation of apoptotic signaling pathway negative regulation of cellular process signal transduction intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of signaling negative regulation of response to stimulus negative regulation of programmed cell death negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of signal transduction neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of cell communication regulation of apoptotic signaling pathway regulation of multicellular organismal development regulation of developmental process regulation of biomineral tissue development positive regulation of developmental process positive regulation of biomineral tissue development regulation of multicellular organismal process integrated stress response signaling intracellular signaling cassette negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process cellular response to amino acid starvation response to amino acid starvation regulation of localization sodium-dependent phosphate transport regulation of transport transport regulation of phosphate transport regulation of sodium-dependent phosphate transport establishment of localization localization positive regulation of transport positive regulation of sodium-dependent phosphate transport phosphate ion transport inorganic anion transport positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process response to organic substance cellular response to topologically incorrect protein endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein response to topologically incorrect protein cellular response to organic substance HRI-mediated signaling regulation of osteoblast differentiation regulation of cell differentiation osteoblast differentiation negative regulation of potassium ion transport regulation of potassium ion transport negative regulation of monoatomic ion transport regulation of monoatomic ion transport negative regulation of transport metal ion transport monoatomic ion transport potassium ion transport monoatomic cation transport regulation of metal ion transport regulation of cytokine production cytokine production regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of multicellular organismal process positive regulation of vascular endothelial growth factor production positive regulation of cytokine production cellular response to leucine starvation nervous system development generation of neurons neurogenesis neuron differentiation PERK-mediated unfolded protein response ER-nucleus signaling pathway regulation of synaptic plasticity trans-synaptic signaling modulation of chemical synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of biological quality intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress transcription by RNA polymerase I regulation of transcription by RNA polymerase I positive regulation of transcription by RNA polymerase I muscle cell apoptotic process positive regulation of smooth muscle cell apoptotic process smooth muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of smooth muscle cell apoptotic process positive regulation of muscle cell apoptotic process vascular associated smooth muscle cell apoptotic process positive regulation of vascular associated smooth muscle cell apoptotic process regulation of vascular associated smooth muscle cell apoptotic process negative regulation of cold-induced thermogenesis adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis negative regulation of multicellular organismal process regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding negative regulation of molecular function protein localization cellular localization cellular macromolecule localization macromolecule localization cell surface receptor signaling pathway canonical Wnt signaling pathway Wnt signaling pathway regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion cell-substrate adhesion positive regulation of cell-matrix adhesion cell adhesion cell-matrix adhesion positive regulation of cell-substrate adhesion regulation of cell-matrix adhesion axon extension positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of neurogenesis neuron projection development regulation of cell development cell projection morphogenesis neuron projection morphogenesis positive regulation of cell projection organization positive regulation of developmental growth regulation of cell projection organization positive regulation of cell development developmental growth involved in morphogenesis regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization plasma membrane bounded cell projection morphogenesis cell growth regulation of axon extension cellular component organization regulation of nervous system development regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis positive regulation of axon extension cellular component organization or biogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size cerebral cortex cell migration head development forebrain development brain development cerebral cortex radially oriented cell migration pallium development cerebral cortex development telencephalon cell migration central nervous system development forebrain cell migration cell migration telencephalon development cell motility mitochondrial calcium ion homeostasis positive regulation of neuron projection development organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process protein metabolic process organic substance catabolic process developmental maturation synapse maturation regulation of synapse organization regulation of synapse maturation cell junction organization regulation of synapse structure or activity synapse organization regulation of dendritic spine development dendrite development dendritic spine development detection of external stimulus system process detection of stimulus involved in sensory perception of pain nervous system process response to external stimulus sensory perception of temperature stimulus sensory perception of pain detection of temperature stimulus involved in sensory perception response to temperature stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of temperature stimulus detection of stimulus involved in sensory perception detection of temperature stimulus involved in sensory perception of pain positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway regulation of Wnt signaling pathway positive regulation of signaling cell proliferation in forebrain cell population proliferation neural precursor cell proliferation TOR signaling postsynapse organization regulation of postsynapse organization neuron cellular homeostasis protein localization to microtubule cytoskeleton protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to organelle protein localization to centrosome positive regulation of protein metabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process regulation of protein metabolic process regulation of catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis pyramidal neuron development glial cell migration central nervous system neuron development telencephalon glial cell migration central nervous system neuron differentiation gliogenesis radial glia-guided pyramidal neuron migration pyramidal neuron migration to cerebral cortex neuron migration forebrain generation of neurons forebrain neuron development cerebral cortex radial glia-guided migration forebrain neuron differentiation pyramidal neuron differentiation organelle assembly plasma membrane bounded cell projection assembly cellular component biogenesis organelle organization cellular component assembly cilium assembly cilium organization cell projection assembly non-motile cilium assembly microtubule cytoskeleton organization microtubule-based process cytoskeleton organization synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic neuroblast proliferation positive regulation of cell population proliferation regulation of neuroblast proliferation regulation of neural precursor cell proliferation positive regulation of neural precursor cell proliferation regulation of cell population proliferation positive regulation of neuroblast proliferation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex transcription regulator complex cytoplasm cell projection neuron projection plasma membrane bounded cell projection RNA polymerase II transcription regulator complex nuclear protein-containing complex CHOP-ATF4 complex ATF4-CREB1 transcription factor complex centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle ATF1-ATF4 transcription factor complex nuclear periphery inclusion body Lewy body Lewy body core cell leading edge plasma membrane membrane leading edge membrane somatodendritic compartment neuron projection membrane cell periphery dendrite membrane dendrite dendritic tree plasma membrane region cell projection membrane cytosol microtubule associated complex kinesin complex synapse cell junction glutamatergic synapse perinuclear region of cytoplasm axon cell body intermediate filament cytoskeleton transport vesicle intracellular vesicle endomembrane system presynapse cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle cilium ciliary basal body polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex mitochondrion growth cone distal axon central region of growth cone site of polarized growth GABA-ergic synapse postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse ciliary base catalytic complex dynein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004827	Basic-leucine zipper domain	Domain
A	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily
A	IPR026081	Disrupted in schizophrenia 1	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.