6B29

Crystal structure of the second SH3 domain of STAC3 (309-364)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07653	e6b29A1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF07653	ECOD (1.6)
B	PF07653	e6b29B1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF07653	ECOD (1.6)
C	PF07653	e6b29C1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF07653	ECOD (1.6)
D	PF07653	e6b29D1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF07653	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF07653	Variant SH3 domain (SH3_2)	Variant SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	SH3 and cysteine-rich domain-containing protein 3	cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	developmental process myotube cell development skeletal muscle fiber development cellular developmental process skeletal muscle tissue development animal organ development cell development tissue development muscle cell differentiation myotube differentiation muscle structure development skeletal muscle organ development muscle cell development cell differentiation anatomical structure development developmental process myotube cell development skeletal muscle fiber development cellular developmental process skeletal muscle tissue development animal organ development cell development tissue development muscle cell differentiation myotube differentiation muscle structure development skeletal muscle organ development muscle cell development cell differentiation anatomical structure development cellular process muscle tissue development muscle organ development striated muscle cell differentiation positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport positive regulation of cation transmembrane transport positive regulation of calcium ion transport regulation of voltage-gated calcium channel activity calcium ion transport positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation transport regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization regulation of cation channel activity positive regulation of cation channel activity inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport transport monoatomic ion transmembrane transport positive regulation of voltage-gated calcium channel activity regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport metal ion transport regulation of transporter activity regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of molecular function positive regulation of calcium ion transmembrane transporter activity positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport monoatomic ion transport regulation of metal ion transport regulation of monoatomic ion transmembrane transporter activity regulation of transport positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport trans-synaptic signaling signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling neuromuscular synaptic transmission	cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity synapse cell junction extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity synapse cell junction extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane intracellular anatomical structure cytoplasm cytosol protein-containing complex plasma membrane protein complex voltage-gated calcium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex calcium channel complex monoatomic ion channel complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR039688	STAC1/2/3	Family
A, B, C, D	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
A, B, C, D	IPR001452	SH3 domain	Domain
A, B, C, D	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR035736	Stac3, first SH3 domain	Domain
A, B, C, D	IPR046349	C1-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q96MF2	Bailey-Bloch congenital myopathy Hepatomegaly liver cancer arthrogryposis colorectal cancer liver neoplasm autism spectrum disorder malignant hyperthermia of anesthesia heart disease tuberculosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.