6ATG

Insights to complement factor H recruitment by the borrelial CspZ protein as revealed by structural analysis

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00084	e6atgA1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: PF00084	ECOD (1.6)
D	PF00084	e6atgD1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: PF00084	ECOD (1.6)
B	PF22487	e6atgB1	A: alpha bundles	X: Complement regulator-acquiring surface protein 2 (CRASP-2) (From Topology)	H: Complement regulator-acquiring surface protein 2 (CRASP-2) (From Topology)	T: Complement regulator-acquiring surface protein 2 (CRASP-2)	F: PF22487	ECOD (1.6)
C	PF22487	e6atgC1	A: alpha bundles	X: Complement regulator-acquiring surface protein 2 (CRASP-2) (From Topology)	H: Complement regulator-acquiring surface protein 2 (CRASP-2) (From Topology)	T: Complement regulator-acquiring surface protein 2 (CRASP-2)	F: PF22487	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
D	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
B	1.20.120.1640	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)		CATH (4.3.0)
C	1.20.120.1640	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF00084	Sushi repeat (SCR repeat) (Sushi)	Sushi repeat (SCR repeat)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	HCG40889, isoform CRA_b	opsonin binding protein binding binding complement component C3b binding complement binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding identical protein binding heparan sulfate proteoglycan binding proteoglycan binding	regulation of humoral immune response regulation of immune effector process regulation of defense response humoral immune response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of biological process complement activation, alternative pathway response to biotic stimulus positive regulation of response to stimulus complement activation positive regulation of immune response response to stress regulation of humoral immune response regulation of immune effector process regulation of defense response humoral immune response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of biological process complement activation, alternative pathway response to biotic stimulus positive regulation of response to stimulus complement activation positive regulation of immune response response to stress regulation of response to stress innate immune response regulation of immune system process response to external biotic stimulus positive regulation of immune system process regulation of biological process regulation of complement activation, alternative pathway immune response response to other organism defense response regulation of innate immune response biological regulation defense response to symbiont response to external stimulus immune effector process regulation of response to stimulus immune system process defense response to other organism regulation of immune response regulation of complement activation activation of immune response regulation of cellular process regulation of complement-dependent cytotoxicity cellular process regulation of cell killing complement-dependent cytotoxicity cell killing organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular region extracellular space cellular anatomical entity blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex extracellular region extracellular space cellular anatomical entity blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex endopeptidase complex serine-type endopeptidase complex serine-type peptidase complex other organism part symbiont cell surface
B, C	Complement regulator-acquiring surface protein 2 (CRASP-2)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR000436	Sushi/SCR/CCP domain	Domain
A, D	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D	Pharos: P08603	age-related macular degeneration complement factor H deficiency age related macular degeneration 4 basal laminar drusen atypical hemolytic-uremic syndrome hemolytic uremic syndrome, atypical, susceptibility to, 1 membranoproliferative glomerulonephritis meningococcal infection hemolytic-uremic syndrome Doyne honeycomb retinal dystrophy primary immunodeficiency disease IgA glomerulonephritis macular degeneration Emery-Dreifuss muscular dystrophy pituitary cancer age-related macular degeneration complement factor H deficiency age related macular degeneration 4 basal laminar drusen atypical hemolytic-uremic syndrome hemolytic uremic syndrome, atypical, susceptibility to, 1 membranoproliferative glomerulonephritis meningococcal infection hemolytic-uremic syndrome Doyne honeycomb retinal dystrophy primary immunodeficiency disease IgA glomerulonephritis macular degeneration Emery-Dreifuss muscular dystrophy pituitary cancer hemolytic anemia psoriasis interstitial lung disease adrenal cortex carcinoma limb-girdle muscular dystrophy Antibody Deficiency Syndrome lung carcinoma bacterial infectious disease malignant mesothelioma blindness (disorder) non-small cell lung carcinoma pancreatic ductal adenocarcinoma Duchenne muscular dystrophy Pick disease facioscapulohumeral muscular dystrophy retinal degeneration invasive ductal breast carcinoma lung adenocarcinoma atopic eczema medulloblastoma breast carcinoma cystic fibrosis oligodendroglioma drug-induced liver injury pancreatic intraductal papillary-mucinous carcinoma ductal breast carcinoma in situ pilocytic astrocytoma HELLP syndrome primary membranoproliferative glomerulonephritis wet macular degeneration immunoglobulin-mediated membranoproliferative glomerulonephritis juvenile dermatomyositis lung cancer malignant colon neoplasm Becker muscular dystrophy breast fibroadenoma dense deposit disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.