4D6K

Structure of DNTTIP1 dimerisation domain.

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF18192	e4d6kA1	A: alpha duplicates or obligate multimers	X: DNTTIP1 dimerisation domain (From Topology)	H: DNTTIP1 dimerisation domain (From Topology)	T: DNTTIP1 dimerisation domain	F: PF18192	ECOD (1.6)
B	PF18192	e4d6kB1	A: alpha duplicates or obligate multimers	X: DNTTIP1 dimerisation domain (From Topology)	H: DNTTIP1 dimerisation domain (From Topology)	T: DNTTIP1 dimerisation domain	F: PF18192	ECOD (1.6)
C	PF18192	e4d6kC1	A: alpha duplicates or obligate multimers	X: DNTTIP1 dimerisation domain (From Topology)	H: DNTTIP1 dimerisation domain (From Topology)	T: DNTTIP1 dimerisation domain	F: PF18192	ECOD (1.6)
D	PF18192	e4d6kD1	A: alpha duplicates or obligate multimers	X: DNTTIP1 dimerisation domain (From Topology)	H: DNTTIP1 dimerisation domain (From Topology)	T: DNTTIP1 dimerisation domain	F: PF18192	ECOD (1.6)
E	PF18192	e4d6kE1	A: alpha duplicates or obligate multimers	X: DNTTIP1 dimerisation domain (From Topology)	H: DNTTIP1 dimerisation domain (From Topology)	T: DNTTIP1 dimerisation domain	F: PF18192	ECOD (1.6)
F	PF18192	e4d6kF1	A: alpha duplicates or obligate multimers	X: DNTTIP1 dimerisation domain (From Topology)	H: DNTTIP1 dimerisation domain (From Topology)	T: DNTTIP1 dimerisation domain	F: PF18192	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF18192	DNTTIP1 dimerisation domain (DNTTIP1_dimer)	DNTTIP1 dimerisation domain	This is the N-terminal domain of DNTTIP1, a protein that forms part of a novel histone deacetylase complex present in Homo sapiens. Histone deacetylase complexes comprise DNTTIP1, histone deacetylase (HDAC) and the repressor protein MIDEAS. The acety ...	This is the N-terminal domain of DNTTIP1, a protein that forms part of a novel histone deacetylase complex present in Homo sapiens. Histone deacetylase complexes comprise DNTTIP1, histone deacetylase (HDAC) and the repressor protein MIDEAS. The acetylation of histone tails plays a critical role in determining the accessibility of chromatin to transcriptional regulators and RNA polymerase complexes. This N-terminal domain is responsible for dimerization of histone deacetylase 1(HDAC1). The N-terminal domain also interacts and mediates the assembly of the HDAC1- MIDEAS complex [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1	DNA binding binding organic cyclic compound binding nucleic acid binding identical protein binding protein binding protein homodimerization activity protein dimerization activity protein-containing complex binding chromatin binding nucleosome binding	-	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen histone deacetylase complex intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen histone deacetylase complex intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen nucleolus intracellular non-membrane-bounded organelle non-membrane-bounded organelle chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR049121	TdIF1, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR041384	DNTTIP1, dimerisation domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR026064	Terminal deoxynucleotidyltransferase-interacting factor 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9H147	malignant ependymoma ovarian cancer malignant pancreatic neoplasm pancreatic ductal adenocarcinoma medulloblastoma Sjogren syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.