3UD2

Crystal structure of Selenomethionine ZU5A-ZU5B protein domains of human erythrocyte ankyrin

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth C]	SCOP2B Superfamily	ZU5 domain-like	8019804	3002026	SCOP2B (2022-06-29)
A [auth C]	SCOP2B Superfamily	ZU5 domain-like	8102945	3002026	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	ZU5 domain-like	8019804	3002026	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	ZU5 domain-like	8102945	3002026	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ZU5 domain-like	8019804	3002026	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ZU5 domain-like	8102945	3002026	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF00791	e3ud2C3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: ZU5/Nup98-C/GAIN-B autoproteolytic domain-related (From Topology)	T: ZU5/Nup98-C/GAIN-B autoproteolytic domain-related	F: PF00791	ECOD (1.6)
C [auth A]	PF00791	e3ud2A5	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: ZU5/Nup98-C/GAIN-B autoproteolytic domain-related (From Topology)	T: ZU5/Nup98-C/GAIN-B autoproteolytic domain-related	F: PF00791	ECOD (1.6)
B	PF00791	e3ud2B5	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: ZU5/Nup98-C/GAIN-B autoproteolytic domain-related (From Topology)	T: ZU5/Nup98-C/GAIN-B autoproteolytic domain-related	F: PF00791	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth C]	2.60.220.30	Mainly Beta	Sandwich	Chondroitinase Ac	Chain A, domain 3	CATH (4.3.0)
C [auth A]	2.60.220.30	Mainly Beta	Sandwich	Chondroitinase Ac	Chain A, domain 3	CATH (4.3.0)
B	2.60.220.30	Mainly Beta	Sandwich	Chondroitinase Ac	Chain A, domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B, C [auth A]	PF00791	ZU5 domain (ZU5)	ZU5 domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B, C [auth A]	Ankyrin-1	cytoskeletal protein binding spectrin binding protein-containing complex binding protein binding binding protein phosphatase binding phosphatase binding enzyme binding transmembrane transporter binding structural constituent of cytoskeleton structural molecule activity protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity cytoskeletal protein binding spectrin binding protein-containing complex binding protein binding binding protein phosphatase binding phosphatase binding enzyme binding transmembrane transporter binding structural constituent of cytoskeleton structural molecule activity protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity ATPase binding	positive regulation of organelle organization regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization biological regulation positive regulation of biological process regulation of organelle organization cellular component organization organelle organization cellular process cellular component organization or biogenesis positive regulation of cellular process protein localization positive regulation of organelle organization regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization biological regulation positive regulation of biological process regulation of organelle organization cellular component organization organelle organization cellular process cellular component organization or biogenesis positive regulation of cellular process protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity maintenance of cell polarity maintenance of epithelial cell apical/basal polarity maintenance of apical/basal cell polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity transport establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport establishment of localization Golgi vesicle transport vesicle-mediated transport cellular response to stimulus response to stimulus signaling signal transduction cell communication cytoskeleton organization secretion by cell exocytosis secretion export from cell	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane M band intracellular anatomical structure sarcomere intracellular organelle cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane M band intracellular anatomical structure sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber A band cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle Z disc I band ankyrin-1 complex protein-containing complex membrane protein complex cytosol sarcolemma basal part of cell basal plasma membrane basolateral plasma membrane cell projection neuron projection plasma membrane bounded cell projection cytoskeleton axon cell leading edge axolemma leading edge membrane neuron projection membrane main axon cell projection membrane membrane-bounded organelle intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum sarcoplasmic reticulum spectrin-associated cytoskeleton cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B, C [auth A]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A [auth C], B, C [auth A]	IPR040745	Ankyrin, UPA domain	Domain
A [auth C], B, C [auth A]	IPR000906	ZU5 domain	Domain
A [auth C], B, C [auth A]	IPR002110	Ankyrin repeat	Repeat
A [auth C], B, C [auth A]	IPR011029	Death-like domain superfamily	Homologous Superfamily
A [auth C], B, C [auth A]	IPR000488	Death domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C], B, C [auth A]	Pharos: P16157	hereditary spherocytosis hereditary spherocytosis type 1 8p11.2 deletion syndrome Bone Diseases, Developmental familial hemolytic anemia hereditary elliptocytosis pilocytic astrocytoma subependymal giant cell astrocytoma hemolytic anemia myopathy primitive neuroectodermal tumor type 2 diabetes mellitus congenital anemia malignant ependymoma maturity-onset diabetes of the young hereditary spherocytosis hereditary spherocytosis type 1 8p11.2 deletion syndrome Bone Diseases, Developmental familial hemolytic anemia hereditary elliptocytosis pilocytic astrocytoma subependymal giant cell astrocytoma hemolytic anemia myopathy primitive neuroectodermal tumor type 2 diabetes mellitus congenital anemia malignant ependymoma maturity-onset diabetes of the young osteosarcoma atypical teratoid rhabdoid tumor cystic fibrosis glioblastoma malignant glioma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.