Annotations: 2ZLE

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2zlea1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d2zlea3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2zleb1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2zleb3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d2zlec1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d2zlec3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d2zlee1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d2zlee3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G	d2zleg1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G	d2zleg3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
H	d2zleh1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
H	d2zleh3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
I	d2zlei1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
I	d2zlei3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
K	d2zlek1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
K	d2zlek3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
L	d2zlel1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
L	d2zlel3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
M	d2zlem1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
M	d2zlem3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d2zlef1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d2zlef3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
J	d2zlej1	All beta proteins	PDZ domain-like	PDZ domain-like	HtrA-like serine proteases	Protease Do (DegP, HtrA), C-terminal domains	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
J	d2zlej3	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	Protease Do (DegP, HtrA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	PDZ domain-like	8040752	3000388	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Trypsin-like serine proteases	8040753	3000114	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Porins	8071276	3000224	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trypsin_2	e2zleA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
A	PDZ_2	e2zleA4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
B	Trypsin_2	e2zleB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
B	PDZ_2	e2zleB4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
C	Trypsin_2	e2zleC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
C	PDZ_2	e2zleC4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
E	Trypsin_2	e2zleE1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
E	PDZ_2	e2zleE4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
G	Trypsin_2	e2zleG1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
G	PDZ_2	e2zleG4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
H	Trypsin_2	e2zleH1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
H	PDZ_2	e2zleH4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
I	Trypsin_2	e2zleI1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
I	PDZ_2	e2zleI4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
K	Trypsin_2	e2zleK1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
K	PDZ_2	e2zleK4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
L	Trypsin_2	e2zleL1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
L	PDZ_2	e2zleL4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
M	Trypsin_2	e2zleM1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
M	PDZ_2	e2zleM4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
F	Trypsin_2	e2zleF1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
F	PDZ_2	e2zleF4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
J	Trypsin_2	e2zleJ1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_2	ECOD (1.6)
J	PDZ_2	e2zleJ4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)
D	Porin_1	e2zleD1	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Porin	F: Porin_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, E, F A, B, C, E, F, G, H, I, J, K, L, M	PF13365	Trypsin-like peptidase domain (Trypsin_2)	Trypsin-like peptidase domain	This family includes trypsin-like peptidase domains.	Domain
A, B, C, E, F A, B, C, E, F, G, H, I, J, K, L, M	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain
D	PF00267	Gram-negative porin (Porin_1)	Gram-negative porin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, E, F A, B, C, E, F, G, H, I, J, K, L, M	Protease do	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity identical protein binding protein binding binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process chaperone-mediated protein folding response to oxidative stress response to stimulus response to stress proteolysis response to heat response to abiotic stimulus response to temperature stimulus organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process protein quality control for misfolded or incompletely synthesized proteins organic substance catabolic process	cell periphery plasma membrane membrane cellular anatomical entity periplasmic space outer membrane-bounded periplasmic space cell envelope
D	Outer membrane protein C	protein binding binding virus receptor activity exogenous protein binding wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity cation binding ion binding metal ion binding small molecule binding protein binding binding virus receptor activity exogenous protein binding wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity cation binding ion binding metal ion binding small molecule binding identical protein binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction transmembrane transport localization transport monoatomic ion transmembrane transport monoatomic ion transport establishment of localization	protein-containing complex membrane pore complex membrane protein complex cellular anatomical entity cell periphery cell outer membrane external encapsulating structure cell envelope outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, E, F A, B, C, E, F, G, H, I, J, K, L, M	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, B, C, E, F A, B, C, E, F, G, H, I, J, K, L, M	IPR001940	Peptidase S1C	Family
A, B, C, E, F A, B, C, E, F, G, H, I, J, K, L, M	IPR036034	PDZ superfamily	Homologous Superfamily
A, B, C, E, F A, B, C, E, F, G, H, I, J, K, L, M	IPR011782	Peptidase S1C, Do	Family
A, B, C, E, F A, B, C, E, F, G, H, I, J, K, L, M	IPR001478	PDZ domain	Domain
D	IPR001897	Porin, gammaproteobacterial	Family
D	IPR023614	Porin domain superfamily	Homologous Superfamily
D	IPR001702	Porin, Gram-negative type	Family
D	IPR013793	Porin, Gram-negative type, conserved site	Conserved Site