Annotations: 2V75

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Nab2 N-terminal domain-like	8046557	4005151	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PWI domain	8102756	3000964	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF11517	e2v75A1	A: alpha arrays	X: PWI domain-like	H: YugE-like (From Topology)	T: YugE-like	F: PF11517	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.340.40	Mainly Alpha	Orthogonal Bundle	Endonuclease III	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF11517	Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) (Nab2)	Nuclear abundant poly(A) RNA-bind protein 2 (Nab2)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN NAB2	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding ribonuclease P RNA binding rRNA binding 5S rRNA binding 7S RNA binding poly(A) binding poly-purine tract binding single-stranded RNA binding cation binding transition metal ion binding RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding ribonuclease P RNA binding rRNA binding 5S rRNA binding 7S RNA binding poly(A) binding poly-purine tract binding single-stranded RNA binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding tRNA binding	regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process positive regulation of mRNA metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of RNA metabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay catabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process macromolecule catabolic process mRNA destabilization negative regulation of mRNA metabolic process regulation of mRNA catabolic process organic substance metabolic process positive regulation of biosynthetic process negative regulation of cellular process regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of catabolic process RNA destabilization nuclear-transcribed mRNA catabolic process biological regulation negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process regulation of cellular biosynthetic process regulation of mRNA stability positive regulation of catabolic process negative regulation of biosynthetic process positive regulation of gene expression positive regulation of mRNA catabolic process regulation of RNA stability cellular process regulation of mRNA metabolic process organic substance catabolic process positive regulation of cellular biosynthetic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization DNA-templated transcription regulation of transcription by RNA polymerase III organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase III RNA biosynthetic process nucleic acid biosynthetic process transcription by RNA polymerase III regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR049017	Nab2, type CCCH zinc finger 4	Domain
A	IPR048410	RNA-binding, Nab2-type zinc finger	Domain
A	IPR041044	Nuclear polyadenylated RNA-binding 2 protein, CCCH zinc finger 1	Domain
A	IPR040366	Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14	Family
A	IPR021083	Nuclear abundant poly(A) RNA-binding protein Nab2, N-terminal	Domain
A	IPR043094	Nab2/ZC3H14, N-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.