2O2T

The crystal structure of the 1st PDZ domain of MPDZ

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2o2ta1	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	Multiple PDZ domain protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2o2ta2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2o2tb1	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	Multiple PDZ domain protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2o2tb2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e2o2tA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
B	PF00595	e2o2tB1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Multiple PDZ domain protein	-	cellular component organization organelle organization microtubule organizing center organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization tight junction organization cellular component biogenesis cell junction organization cellular component assembly tight junction assembly cell junction assembly cellular component organization organelle organization microtubule organizing center organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization tight junction organization cellular component biogenesis cell junction organization cellular component assembly tight junction assembly cell junction assembly cell-cell junction assembly cell-cell junction organization regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation regulation of microtubule-based process regulation of organelle organization regulation of microtubule cytoskeleton organization	apical part of cell cellular anatomical entity cell periphery membrane plasma membrane plasma membrane region apical plasma membrane postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization organelle synapse cell junction apical part of cell cellular anatomical entity cell periphery membrane plasma membrane plasma membrane region apical plasma membrane postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization organelle synapse cell junction asymmetric synapse cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm apicolateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004172	L27 domain	Domain
A, B	IPR036034	PDZ superfamily	Homologous Superfamily
A, B	IPR036892	L27 domain superfamily	Homologous Superfamily
A, B	IPR032078	Multiple PDZ domain protein, unstructured region	Domain
A, B	IPR001478	PDZ domain	Domain
A, B	IPR015132	L27-2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O75970	hydrocephalus, nonsyndromic, autosomal recessive 2 hydrocephalus visual epilepsy Jacksonian Seizure lung cancer malignant mesothelioma non-small cell lung carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm alcohol withdrawal intellectual disability large cell medulloblastoma lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia hydrocephalus, nonsyndromic, autosomal recessive 2 hydrocephalus visual epilepsy Jacksonian Seizure lung cancer malignant mesothelioma non-small cell lung carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm alcohol withdrawal intellectual disability large cell medulloblastoma lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cystic fibrosis sinusitis invasive ductal breast carcinoma lung adenocarcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma alcohol abuse progressive supranuclear palsy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.