2NAN

NMR structure of human DCL-1 (CD302) extracellular domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2nana1	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2nana2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00059	e2nanA1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CD302 antigen	binding carbohydrate binding molecular transducer activity signaling receptor activity	localization import into cell transport phagocytosis cellular process endocytosis establishment of localization vesicle-mediated transport	cell projection actin-based cell projection microvillus cellular anatomical entity plasma membrane bounded cell projection cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane cell cortex intracellular anatomical structure cytoplasm cell projection actin-based cell projection microvillus cellular anatomical entity plasma membrane bounded cell projection cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane cell cortex intracellular anatomical structure cytoplasm filopodium

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001304	C-type lectin-like	Domain
A	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A	IPR016187	C-type lectin fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8IX05	medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis adrenal cortex carcinoma atypical teratoid rhabdoid tumor breast carcinoma Duchenne muscular dystrophy glioblastoma large cell medulloblastoma malignant colon neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma astrocytic tumor medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis adrenal cortex carcinoma atypical teratoid rhabdoid tumor breast carcinoma Duchenne muscular dystrophy glioblastoma large cell medulloblastoma malignant colon neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma astrocytic tumor B-cell chronic lymphocytic leukemia breast fibroadenoma ductal breast carcinoma in situ Hashimoto thyroiditis lung adenocarcinoma malignant mesothelioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema breast cancer Down syndrome Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma lung cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.