2N80

p75NTR DD:RhoGDI

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2n80b_	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	RhoGDI-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2n80a_	All alpha proteins	DEATH domain	DEATH domain	DEATH domain, DD	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	E set domains	8055013	3000070	SCOP2B (2022-06-29)
A	SCOP2 Family	DEATH domain DD	8073229	4000378	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DEATH domain	8073230	3000069	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF02115	e2n80B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02115	ECOD (1.6)
A	PF00531	e2n80A1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: PF00531	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.70.50.30	Mainly Beta	Distorted Sandwich	Coagulation Factor XIII	Chain A, domain 1	CATH (4.3.0)
A	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF02115	RHO protein GDP dissociation inhibitor (Rho_GDI)	RHO protein GDP dissociation inhibitor	-	Domain
A	PF00531	Death domain (Death)	Death domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Rho GDP-dissociation inhibitor 1	GTPase regulator activity enzyme regulator activity GDP-dissociation inhibitor activity nucleoside-triphosphatase regulator activity Rho GDP-dissociation inhibitor activity molecular function regulator activity enzyme activator activity GTPase activator activity molecular function activator activity	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus semaphorin-plexin signaling pathway signaling biological regulation cell communication cellular process signal transduction protein localization regulation of localization cellular localization cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus semaphorin-plexin signaling pathway signaling biological regulation cell communication cellular process signal transduction protein localization regulation of localization cellular localization regulation of protein localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death small GTPase-mediated signal transduction Rho protein signal transduction intracellular signal transduction intracellular signaling cassette transport regulation of transport regulation of synaptic vesicle cycle synaptic vesicle cycle regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse establishment of localization in cell regulation of signaling regulation of small GTPase mediated signal transduction regulation of signal transduction regulation of Rho protein signal transduction regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication	cell periphery immunological synapse plasma membrane membrane cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle cell periphery immunological synapse plasma membrane membrane cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol Schaffer collateral - CA1 synapse synapse cell junction nucleus intracellular membrane-bounded organelle
A	Tumor necrosis factor receptor superfamily member 16	small GTPase binding protein binding binding enzyme binding GTPase binding amide binding amyloid-beta binding peptide binding molecular transducer activity coreceptor activity signaling receptor activity neurotrophin binding nerve growth factor binding growth factor binding small GTPase binding protein binding binding enzyme binding GTPase binding amide binding amyloid-beta binding peptide binding molecular transducer activity coreceptor activity signaling receptor activity neurotrophin binding nerve growth factor binding growth factor binding calmodulin binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding transmembrane signaling receptor activity death receptor activity	cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling biological regulation cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cellular process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway positive regulation of response to stimulus signal transduction positive regulation of cellular process positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus apoptotic process programmed cell death positive regulation of signaling regulation of apoptotic signaling pathway epithelium development epidermis development molting cycle process hair cycle epidermis morphogenesis animal organ development morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis skin development skin epidermis development hair follicle development molting cycle hair cycle process hair follicle morphogenesis positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of miRNA transcription rhythmic process circadian regulation of gene expression circadian rhythm fibroblast proliferation cell population proliferation regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis endothelial cell proliferation negative regulation of biological process angiogenesis negative regulation of endothelial cell proliferation tube morphogenesis negative regulation of cellular process epithelial cell proliferation blood vessel development negative regulation of cell population proliferation negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis blood vessel morphogenesis tube development blood vessel endothelial cell proliferation involved in sprouting angiogenesis sprouting angiogenesis vasculature development circulatory system development regulation of endothelial cell proliferation regulation of cell population proliferation anatomical structure formation involved in morphogenesis regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion nerve development small GTPase-mediated signal transduction Rho protein signal transduction intracellular signal transduction intracellular signaling cassette artery development aorta development dorsal aorta development response to fibroblast growth factor cellular response to growth factor stimulus negative regulation of signaling negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction fibroblast growth factor receptor signaling pathway response to growth factor cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization regulation of animal organ morphogenesis regulation of developmental process regulation of odontogenesis of dentin-containing tooth regulation of odontogenesis odontogenesis of dentin-containing tooth odontogenesis positive regulation of odontogenesis positive regulation of developmental process positive regulation of odontogenesis of dentin-containing tooth positive regulation of animal organ morphogenesis positive regulation of multicellular organismal process animal organ morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of molecular function regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity protein metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis positive regulation of cell population proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation detection of external stimulus detection of stimulus detection of temperature stimulus response to external stimulus response to abiotic stimulus response to temperature stimulus detection of abiotic stimulus establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization protein transport establishment of localization in cell intracellular protein transport neuron apoptotic process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation cellular component organization or biogenesis plasma membrane bounded cell projection organization axon guidance axon development cell morphogenesis involved in neuron differentiation generation of neurons neuron projection guidance neuron development regulation of hair cycle regulation of multicellular organismal development negative regulation of developmental process regulation of hair follicle development negative regulation of hair follicle development negative regulation of multicellular organismal process cellular response to nitrogen compound response to organic substance response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to organic substance response to amyloid-beta	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity membrane cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol neuromuscular junction synapse somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity membrane cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol neuromuscular junction synapse neuron spine neuron projection dendritic spine plasma membrane bounded cell projection cell projection postsynapse dendrite dendritic tree cell surface cell periphery plasma membrane presynapse growth cone axon distal axon site of polarized growth membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle extracellular region postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR024792	Rho GDP-dissociation inhibitor domain superfamily	Homologous Superfamily
B	IPR014756	Immunoglobulin E-set	Homologous Superfamily
B	IPR000406	Rho protein GDP-dissociation inhibitor	Family
A	IPR000488	Death domain	Domain
A	IPR022325	Tumour necrosis factor receptor 16	Family
A	IPR041448	Tumor necrosis factor receptor member 16, transmembrane domain	Domain
A	IPR034046	Tumor necrosis factor receptor 16, N-terminal	Domain
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR001368	TNFR/NGFR cysteine-rich region	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P52565	nephrotic syndrome, type 8 breast carcinoma HIV infectious disease keloid Neoplasm Metastasis Pick disease acute myeloid leukemia chronic obstructive pulmonary disease large cell medulloblastoma malignant mesothelioma polycystic ovary syndrome breast cancer congestive heart failure lung cancer medulloblastoma nephrotic syndrome, type 8 breast carcinoma HIV infectious disease keloid Neoplasm Metastasis Pick disease acute myeloid leukemia chronic obstructive pulmonary disease large cell medulloblastoma malignant mesothelioma polycystic ovary syndrome breast cancer congestive heart failure lung cancer medulloblastoma ovarian cancer psoriasis glioblastoma malignant glioma
A	Pharos: P08138	visual epilepsy Nerve Degeneration prostate cancer pilocytic astrocytoma psoriasis breast cancer depressive disorder heart disease medulloblastoma adrenal cortex carcinoma schizophrenia neurodegenerative disease osteosarcoma malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.