2KYR

Solution structure of Enzyme IIB subunit of PTS system from Escherichia coli K12. Northeast Structural Genomics Consortium target ER315/Ontario Center for Structural Proteomics target ec0544

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2kyra_	Alpha and beta proteins (a/b)	Phosphotyrosine protein phosphatases I-like	PTS system IIB component-like	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PTS system Fructose specific IIB subunit-like	8064417	4002238	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PTS system IIB component-like	8064418	3000300	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PTS_IIB	e2kyrA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Phosphotyrosine protein phosphatases I-like	F: PTS_IIB	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02302	PTS system, Lactose/Cellobiose specific IIB subunit (PTS_IIB)	PTS system, Lactose/Cellobiose specific IIB subunit	The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally ...	The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases. This family also contains the fructose specific IIB subunit.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Fructose-like phosphotransferase enzyme IIB component 1	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups monosaccharide transmembrane transporter activity sugar transmembrane transporter activity protein-N(PI)-phosphohistidine-sugar phosphotransferase activity fructose transmembrane transporter activity hexose transmembrane transporter activity phosphotransferase activity, alcohol group as acceptor active transmembrane transporter activity protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity transporter activity carbohydrate transmembrane transporter activity kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups monosaccharide transmembrane transporter activity sugar transmembrane transporter activity protein-N(PI)-phosphohistidine-sugar phosphotransferase activity fructose transmembrane transporter activity hexose transmembrane transporter activity phosphotransferase activity, alcohol group as acceptor active transmembrane transporter activity protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity protein-phosphocysteine-sugar phosphotransferase activity protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity	phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process import into cell phosphoenolpyruvate-dependent sugar phosphotransferase system transport organic substance transport import across plasma membrane carbohydrate import across plasma membrane carbohydrate transport establishment of localization phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process import into cell phosphoenolpyruvate-dependent sugar phosphotransferase system transport organic substance transport import across plasma membrane carbohydrate import across plasma membrane carbohydrate transport establishment of localization transmembrane transport localization carbohydrate transmembrane transport	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003353	Phosphotransferase system, fructose-specific IIB subunit	Domain
A	IPR003501	Phosphotransferase system, EIIB component, type 2/3	Domain
A	IPR036095	PTS system IIB component-like superfamily	Homologous Superfamily
A	IPR013011	Phosphotransferase system, EIIB component, type 2	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.