2KIT

The solution structure of the reduced yeast TOR1 FATC domain bound to DPC micelles at 298K

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02260	e2kitA1	A: extended segments	X: FATC domain (From Topology)	H: FATC domain (From Topology)	T: FATC domain	F: PF02260	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02260	FATC domain (FATC)	FATC domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Serine/threonine-protein kinase TOR1	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity protein-containing complex binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process sphingolipid biosynthetic process cellular biosynthetic process regulation of lipid metabolic process organonitrogen compound biosynthetic process lipid biosynthetic process regulation of primary metabolic process cellular component biogenesis cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process sphingolipid biosynthetic process cellular biosynthetic process regulation of lipid metabolic process organonitrogen compound biosynthetic process lipid biosynthetic process regulation of primary metabolic process cellular component biogenesis regulation of sphingolipid biosynthetic process organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis regulation of biosynthetic process membrane lipid metabolic process regulation of biological process regulation of membrane lipid metabolic process organonitrogen compound metabolic process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process sphingolipid metabolic process regulation of macromolecule metabolic process regulation of cellular component biogenesis macromolecule biosynthetic process regulation of cellular biosynthetic process biosynthetic process cellular lipid metabolic process metabolic process regulation of macromolecule biosynthetic process regulation of lipid biosynthetic process macromolecule metabolic process membrane lipid biosynthetic process regulation of metabolic process lipid metabolic process translation gene expression translational initiation protein metabolic process snRNA modification RNA metabolic process regulation of snRNA pseudouridine synthesis nucleobase-containing compound metabolic process regulation of RNA metabolic process snRNA metabolic process regulation of nucleobase-containing compound metabolic process pseudouridine synthesis snRNA pseudouridine synthesis nucleic acid metabolic process organic cyclic compound metabolic process RNA modification macromolecule modification ncRNA metabolic process nucleic acid catabolic process ribosome biogenesis ribonucleoprotein complex biogenesis cellular response to heat response to heat response to abiotic stimulus response to temperature stimulus fungal-type cell wall organization cellular component organization fungal-type cell wall organization or biogenesis cell wall organization or biogenesis cell wall organization external encapsulating structure organization regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth negative regulation of cellular catabolic process catabolic process macroautophagy autophagy negative regulation of biological process regulation of autophagy negative regulation of cellular metabolic process cellular catabolic process negative regulation of cellular process process utilizing autophagic mechanism negative regulation of catabolic process negative regulation of metabolic process regulation of catabolic process negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy regulation of cellular catabolic process response to oxidative stress cellular response to chemical stimulus response to chemical cellular response to oxidative stress cellular response to chemical stress RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase I rRNA transcription rRNA metabolic process nucleolar large rRNA transcription by RNA polymerase I nucleobase-containing compound biosynthetic process organic cyclic compound biosynthetic process protein phosphorylation phosphorylation phosphate-containing compound metabolic process protein modification process phosphorus metabolic process peptidyl-serine modification peptidyl-serine phosphorylation peptidyl-amino acid modification TOR signaling signaling intracellular signal transduction cell communication signal transduction cell cycle regulation of cell cycle response to nutrient levels response to nutrient sexual reproduction reproductive process meiotic cell cycle mitochondria-nucleus signaling pathway response to endoplasmic reticulum stress	cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm TORC2 complex protein-containing complex TOR complex intracellular protein-containing complex vacuolar membrane membrane-bounded organelle storage vacuole lytic vacuole cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm TORC2 complex protein-containing complex TOR complex intracellular protein-containing complex vacuolar membrane membrane-bounded organelle storage vacuole lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle organelle membrane fungal-type vacuole membrane Golgi membrane Golgi apparatus endomembrane system endosome membrane endosome intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle TORC1 complex nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR026683	Serine/threonine-protein kinase TOR, catalytic domain	Domain
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR003152	FATC domain	Domain
A	IPR024585	Serine/threonine-protein kinase mTOR domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	Conserved Site
A	IPR009076	FKBP12-rapamycin binding domain	Domain
A	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A	IPR003151	PIK-related kinase, FAT	Domain
A	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Homologous Superfamily
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR036738	FKBP12-rapamycin binding domain superfamily	Homologous Superfamily
A	IPR014009	PIK-related kinase	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Peptides	Alpha-helical peptides	Membrane anchor helices of peripheral proteins	FATC domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.