Annotations: 2K2W

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	NIBRIN-like	8045682	4004613	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	BRCT domain-like	8091435	3000159	SCOP2 (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.10980	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Nibrin, BRCT2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16508	Second BRCT domain on Nijmegen syndrome breakage protein (NIBRIN_BRCT_II)	Second BRCT domain on Nijmegen syndrome breakage protein	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Recombination and DNA repair protein	transcription factor binding protein binding binding DNA-binding transcription factor binding	cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition DNA damage checkpoint signaling response to stimulus signaling G2/M transition of mitotic cell cycle mitotic G2 DNA damage checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition DNA damage checkpoint signaling response to stimulus signaling G2/M transition of mitotic cell cycle mitotic G2 DNA damage checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint cell communication regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling cellular response to stress response to stress mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process DNA damage response negative regulation of cell cycle G2/M phase transition signal transduction in response to DNA damage cellular process negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition double-strand break repair primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process macromolecule metabolic process DNA repair adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process lymphocyte mediated immunity B cell activation involved in immune response cell activation involved in immune response multicellular organism development anatomical structure development organic substance biosynthetic process leukocyte mediated immunity somatic diversification of immune receptors somatic recombination of immunoglobulin genes involved in immune response system development developmental process immune response DNA recombination cellular metabolic process immune effector process somatic diversification of immunoglobulins biosynthetic process B cell mediated immunity isotype switching immune system development immunoglobulin production immunoglobulin production involved in immunoglobulin-mediated immune response cellular biosynthetic process somatic cell DNA recombination lymphocyte activation leukocyte activation somatic diversification of immunoglobulins involved in immune response somatic recombination of immunoglobulin gene segments leukocyte activation involved in immune response lymphocyte activation involved in immune response production of molecular mediator of immune response B cell activation cell activation gene expression macromolecule biosynthetic process immunoglobulin mediated immune response adaptive immune response immune system process somatic diversification of immune receptors via germline recombination within a single locus sexual reproduction reproductive process meiotic cell cycle fibroblast proliferation cell population proliferation regulation of cell population proliferation regulation of fibroblast proliferation telomere organization chromosome organization telomere maintenance cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure Mre11 complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity inclusion body nuclear inclusion body intracellular non-membrane-bounded organelle chromosome membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure Mre11 complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity inclusion body nuclear inclusion body intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A	IPR032429	Nibrin, second BRCT domain	Domain
A	IPR000253	Forkhead-associated (FHA) domain	Domain
A	IPR016592	Nibrin	Family
A	IPR040227	Nibrin-related	Family
A	IPR001357	BRCT domain	Domain
A	IPR013908	Nibrin, C-terminal	Domain
A	IPR043014	Nibrin, second BRCT domain superfamily	Homologous Superfamily
A	IPR036420	BRCT domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.