2ETN

Crystal structure of Thermus aquaticus Gfh1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2etna1	All alpha proteins	Long alpha-hairpin	GreA transcript cleavage protein, N-terminal domain	GreA transcript cleavage protein, N-terminal domain	GreA transcript cleavage protein, N-terminal domain	(Thermus aquaticus ) [TaxId: 271 ],	SCOPe (2.08)
A	d2etna2	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	GreA transcript cleavage factor, C-terminal domain	GreA transcript cleavage factor, C-terminal domain	(Thermus aquaticus ) [TaxId: 271 ],	SCOPe (2.08)
B	d2etnb1	All alpha proteins	Long alpha-hairpin	GreA transcript cleavage protein, N-terminal domain	GreA transcript cleavage protein, N-terminal domain	GreA transcript cleavage protein, N-terminal domain	(Thermus aquaticus ) [TaxId: 271 ],	SCOPe (2.08)
B	d2etnb2	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	GreA transcript cleavage factor, C-terminal domain	GreA transcript cleavage factor, C-terminal domain	(Thermus aquaticus ) [TaxId: 271 ],	SCOPe (2.08)
C	d2etnc1	All alpha proteins	Long alpha-hairpin	GreA transcript cleavage protein, N-terminal domain	GreA transcript cleavage protein, N-terminal domain	GreA transcript cleavage protein, N-terminal domain	(Thermus aquaticus ) [TaxId: 271 ],	SCOPe (2.08)
C	d2etnc2	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	GreA transcript cleavage factor, C-terminal domain	GreA transcript cleavage factor, C-terminal domain	(Thermus aquaticus ) [TaxId: 271 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	GreA transcript cleavage protein N-terminal domain	8027790	4000597	SCOP2 (2022-06-29)
A	SCOP2 Family	GreA transcript cleavage factor C-terminal domain	8027792	4001068	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GreA transcript cleavage protein N-terminal domain	8040169	3000703	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Transcription elongation factor GreA/GreB-like	8040171	3002449	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Transcription elongation factor GreA/GreB-like	8040171	3002449	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GreA transcript cleavage protein N-terminal domain	8040169	3000703	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GreA transcript cleavage protein N-terminal domain	8040169	3000703	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Transcription elongation factor GreA/GreB-like	8040171	3002449	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03449	e2etnA1	A: alpha bundles	X: Long alpha-hairpin	H: GreA transcript cleavage protein, N-terminal domain (From Topology)	T: GreA transcript cleavage protein, N-terminal domain	F: PF03449	ECOD (1.6)
A	PF01272	e2etnA2	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: PF01272	ECOD (1.6)
B	PF03449	e2etnB1	A: alpha bundles	X: Long alpha-hairpin	H: GreA transcript cleavage protein, N-terminal domain (From Topology)	T: GreA transcript cleavage protein, N-terminal domain	F: PF03449	ECOD (1.6)
B	PF01272	e2etnB2	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: PF01272	ECOD (1.6)
C	PF03449	e2etnC1	A: alpha bundles	X: Long alpha-hairpin	H: GreA transcript cleavage protein, N-terminal domain (From Topology)	T: GreA transcript cleavage protein, N-terminal domain	F: PF03449	ECOD (1.6)
C	PF01272	e2etnC2	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: PF01272	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.180	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Transcription elongation factor, GreA/GreB, N-terminal domain	CATH (4.3.0)
A	3.10.50.30	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
B	1.10.287.180	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Transcription elongation factor, GreA/GreB, N-terminal domain	CATH (4.3.0)
B	3.10.50.30	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
C	1.10.287.180	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Transcription elongation factor, GreA/GreB, N-terminal domain	CATH (4.3.0)
C	3.10.50.30	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF03449	Transcription elongation factor, N-terminal (GreA_GreB_N)	Transcription elongation factor, N-terminal	This domain adopts a long alpha-hairpin structure.	Domain
A, B, C	PF01272	Transcription elongation factor, GreA/GreB, C-term (GreA_GreB)	Transcription elongation factor, GreA/GreB, C-term	This domain has an FKBP-like fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	anti-cleavage anti-GreA transcription factor Gfh1	DNA binding binding organic cyclic compound binding nucleic acid binding RNA polymerase binding protein binding enzyme binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression DNA-templated transcription elongation biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR022691	Transcription elongation factor, GreA/GreB, N-terminal	Domain
A, B, C	IPR023459	Transcription elongation factor GreA/GreB family	Family
A, B, C	IPR036805	Transcription elongation factor, GreA/GreB, N-terminal domain superfamily	Homologous Superfamily
A, B, C	IPR036953	Transcription elongation factor GreA/GreB, C-terminal domain superfamily	Homologous Superfamily
A, B, C	IPR018151	Transcription elongation factor, GreA/GreB, conserved site	Conserved Site
A, B, C	IPR001437	Transcription elongation factor, GreA/GreB, C-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.