2EAN

Solution structure of the N-terminal SAM-domain of human KIAA0902 protein (connector enhancer of kinase suppressor of ras 2)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2eana1	All alpha proteins	SAM domain-like	SAM/Pointed domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2eana3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2eana2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SAM/Pointed domain	8080802	3000479	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00536	e2eanA1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: PF00536	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00536	SAM domain (Sterile alpha motif) (SAM_1)	SAM domain (Sterile alpha motif)	It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module ...	It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Connector enhancer of kinase suppressor of ras 2	protein binding binding kinase binding enzyme binding protein kinase binding identical protein binding	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process response to stimulus signaling biological regulation regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication cellular process signal transduction intracellular signal transduction cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process response to stimulus signaling biological regulation regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication cellular process signal transduction intracellular signal transduction cellular component organization cell junction organization postsynapse organization synapse organization cellular component organization or biogenesis	extrinsic component of plasma membrane postsynaptic specialization membrane synapse extrinsic component of postsynaptic density membrane postsynaptic density membrane cell periphery cell junction extrinsic component of postsynaptic specialization membrane asymmetric synapse postsynaptic specialization membrane plasma membrane cellular anatomical entity synaptic membrane extrinsic component of plasma membrane postsynaptic specialization membrane synapse extrinsic component of postsynaptic density membrane postsynaptic density membrane cell periphery cell junction extrinsic component of postsynaptic specialization membrane asymmetric synapse postsynaptic specialization membrane plasma membrane cellular anatomical entity synaptic membrane extrinsic component of synaptic membrane postsynapse postsynaptic density neuron to neuron synapse organelle postsynaptic membrane plasma membrane region extrinsic component of membrane extrinsic component of postsynaptic membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle somatodendritic compartment cell body neuronal cell body intracellular anatomical structure cytoplasm glutamatergic synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A	IPR017874	CRIC domain	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR049628	CNK1-3, SAM domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain
A	IPR010599	Connector enhancer of kinase suppressor of ras 2/3 domain	Domain
A	IPR001660	Sterile alpha motif domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8WXI2	myopathy ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor astrocytic tumor type 2 diabetes mellitus atypical teratoid rhabdoid tumor breast cancer Epileptic encephalopathy intellectual disability, X-linked, syndromic, Houge type lung adenocarcinoma medulloblastoma non-syndromic X-linked intellectual disability pancreatic intraductal papillary-mucinous carcinoma Pick disease myopathy ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor astrocytic tumor type 2 diabetes mellitus atypical teratoid rhabdoid tumor breast cancer Epileptic encephalopathy intellectual disability, X-linked, syndromic, Houge type lung adenocarcinoma medulloblastoma non-syndromic X-linked intellectual disability pancreatic intraductal papillary-mucinous carcinoma Pick disease psoriasis atopic eczema autism spectrum disorder colorectal cancer glioblastoma invasive ductal breast carcinoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma subependymal giant cell astrocytoma attention deficit hyperactivity disorder, inattentive type bipolar disorder ductal breast carcinoma in situ intellectual disability large cell medulloblastoma malignant glioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.