Annotations: 1R5S

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1r5sa1	Membrane and cell surface proteins and peptides	Connexin43	Connexin43	Connexin43	Gap junction alpha-1 protein, C-terminal domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d1r5sa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Connexin43 C-terminal domain-like	8029812	4003910	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Connexin C-terminal domain-like	8042191	3001780	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Connexin43	e1r5sA1	A: extended segments	X: Connexin43 (From Topology)	H: Connexin43 (From Topology)	T: Connexin43	F: Connexin43	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.1130	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Connexin43	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03508	Gap junction alpha-1 protein (Cx43) (Connexin43)	Gap junction alpha-1 protein (Cx43)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Gap junction alpha-1 protein	SH3 domain binding protein binding binding protein domain specific binding protein tyrosine kinase binding kinase binding enzyme binding protein kinase binding signaling receptor binding PDZ domain binding scaffold protein binding beta-catenin binding connexin binding glutathione transmembrane transporter activity SH3 domain binding protein binding binding protein domain specific binding protein tyrosine kinase binding kinase binding enzyme binding protein kinase binding signaling receptor binding PDZ domain binding scaffold protein binding beta-catenin binding connexin binding glutathione transmembrane transporter activity tripeptide transmembrane transporter activity sulfur compound transmembrane transporter activity oligopeptide transmembrane transporter activity amide transmembrane transporter activity transporter activity transmembrane transporter activity modified amino acid transmembrane transporter activity organic anion transmembrane transporter activity monoatomic ion transmembrane transporter activity wide pore channel activity passive transmembrane transporter activity channel activity gap junction channel activity gap junction channel activity involved in cell communication by electrical coupling cytoskeletal protein binding tubulin binding gap junction hemi-channel activity beta-tubulin binding efflux transmembrane transporter activity disordered domain specific binding	heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction blood circulation developmental process heart development heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction blood circulation developmental process heart development multicellular organism development anatomical structure development animal organ development circulatory system development system development protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process transport microtubule-based transport establishment of localization regulation of tube diameter regulation of tube size positive regulation of biological process positive regulation of vasoconstriction vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process blood vessel diameter maintenance regulation of biological quality vasoconstriction regulation of anatomical structure size sensory organ development eye development visual system development camera-type eye development sensory system development lens development in camera-type eye response to stimulus response to stress response to ischemia xenobiotic transport transmembrane transport export from cell export across plasma membrane cardiac muscle cell membrane repolarization membrane repolarization regulation of membrane repolarization ventricular cardiac muscle cell membrane repolarization regulation of cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of membrane potential regulation of multicellular organismal development regulation of developmental process bone mineralization regulation of biomineral tissue development regulation of bone mineralization tissue development ossification biomineral tissue development regulation of ossification epithelium development cellular developmental process cell development developmental maturation epithelial cell differentiation epithelial cell development columnar/cuboidal epithelial cell development anatomical structure maturation cell differentiation epithelial cell maturation cell maturation columnar/cuboidal epithelial cell differentiation columnar/cuboidal epithelial cell maturation establishment of organelle localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle cellular component organization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle cellular component organization or biogenesis microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of cell polarity organelle organization mitotic cell cycle process establishment of mitotic spindle orientation microtubule-based process cytoskeleton organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly gap junction assembly cell-cell junction assembly cell-cell junction organization cell communication by electrical coupling cell communication maintenance of protein location maintenance of location maintenance of location in cell maintenance of protein localization in endoplasmic reticulum maintenance of protein location in cell protein localization to organelle maintenance of protein localization in organelle protein localization to endoplasmic reticulum cell communication by chemical coupling blood vessel morphogenesis tube development vasculature development anatomical structure morphogenesis tube morphogenesis blood vessel development regulation of cellular process regulation of cell communication regulation of cell communication by electrical coupling chronic inflammatory response defense response inflammatory response organic anion transport nitrogen compound transport carboxylic acid transport secretion organic substance transport organic acid transport amino acid transport acidic amino acid transport secretion by cell dicarboxylic acid transport glutamate secretion regulation of localization regulation of transport regulation of transmembrane transporter activity regulation of transporter activity regulation of molecular function regulation of transmembrane transport regulation of defense response regulation of fear response regulation of behavioral fear response positive regulation of response to stimulus regulation of behavior behavioral defense response regulation of response to stress behavioral fear response positive regulation of behavioral fear response multicellular organismal response to stress behavior fear response positive regulation of fear response positive regulation of behavior regulation of response to stimulus positive regulation of defense response catabolic process positive regulation of protein metabolic process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process positive regulation of cell communication regulation of cell communication by chemical coupling positive regulation of cell communication by chemical coupling positive regulation of cellular process bicellular tight junction assembly regulation of bicellular tight junction assembly regulation of cellular component organization tight junction organization apical junction assembly regulation of cellular component biogenesis regulation of cell junction assembly tight junction assembly response to hexose response to organic substance response to monosaccharide response to carbohydrate response to glucose response to chemical response to oxygen-containing compound regulation of reproductive process reproductive process positive regulation of establishment of Sertoli cell barrier sex differentiation regulation of cell differentiation developmental process involved in reproduction Sertoli cell differentiation male gonad development regulation of cell development male sex differentiation positive regulation of developmental process development of primary male sexual characteristics development of primary sexual characteristics positive regulation of cell differentiation reproductive structure development positive regulation of reproductive process gonad development reproductive system development Sertoli cell development positive regulation of cell development establishment of Sertoli cell barrier regulation of establishment of Sertoli cell barrier response to pH response to abiotic stimulus cellular response to stimulus response to mechanical stimulus response to external stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus multi-multicellular organism process placenta development maternal process involved in female pregnancy multicellular organismal reproductive process maternal placenta development female pregnancy multi-organism reproductive process decidualization mesodermal cell differentiation mesoderm morphogenesis embryo development regulation of mesodermal cell differentiation mesoderm formation positive regulation of mesodermal cell differentiation mesoderm development formation of primary germ layer embryonic morphogenesis gastrulation tissue morphogenesis anatomical structure formation involved in morphogenesis cellular response to parathyroid hormone stimulus response to endogenous stimulus cellular response to endogenous stimulus cellular response to chemical stimulus response to parathyroid hormone response to hormone cellular response to organic substance cellular response to hormone stimulus tissue regeneration skeletal muscle tissue regeneration developmental growth growth regeneration cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process positive regulation of organelle organization positive regulation of cellular component organization sexual reproduction meiotic cell cycle process positive regulation of cell cycle process meiotic nuclear division regulation of cell cycle regulation of meiotic cell cycle regulation of cell cycle process organelle fission meiotic cell cycle positive regulation of nuclear division positive regulation of meiotic cell cycle regulation of organelle organization positive regulation of cell cycle regulation of meiotic nuclear division nuclear division regulation of nuclear division positive regulation of meiotic nuclear division cellular response to nitrogen compound response to organonitrogen compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to organonitrogen compound response to amyloid-beta biological process involved in interspecies interaction between organisms response to lipid response to other organism response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin negative regulation of cell population proliferation cell population proliferation endothelial cell proliferation negative regulation of endothelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation response to estradiol response to organic cyclic compound limb development appendage development embryonic limb morphogenesis embryonic appendage morphogenesis appendage morphogenesis embryonic digit morphogenesis limb morphogenesis spermatogenesis male gamete generation gamete generation regulation of membrane depolarization membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization regulation of muscle tissue development positive regulation of striated muscle tissue development regulation of striated muscle tissue development striated muscle tissue development muscle structure development positive regulation of muscle organ development positive regulation of muscle tissue development regulation of muscle organ development muscle tissue development muscle organ development regulation of calcium ion transport regulation of monoatomic ion transport metal ion transport calcium ion transport monoatomic ion transport regulation of metal ion transport monoatomic cation transport heart morphogenesis tissue remodeling animal organ morphogenesis atrial ventricular junction remodeling epididymis development ATP transport nucleotide transport purine ribonucleotide transport carbohydrate derivative transport purine nucleotide transport adenine nucleotide transport nucleobase-containing compound transport organophosphate ester transport regulation of atrial cardiac muscle cell membrane depolarization positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process skeletal system development bone development signaling cell-cell signaling regulation of growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death regulation of cardiac muscle tissue growth cardiac muscle cell proliferation negative regulation of cardiac muscle tissue growth organ growth negative regulation of organ growth regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation cardiac muscle tissue growth striated muscle cell proliferation heart growth regulation of developmental growth negative regulation of heart growth cardiac muscle tissue development negative regulation of developmental process negative regulation of developmental growth negative regulation of multicellular organismal process negative regulation of cardiac muscle cell proliferation cellular response to pH regulation of hormone secretion gonadotropin secretion negative regulation of signaling negative regulation of transport hormone secretion negative regulation of cell communication regulation of secretion by cell negative regulation of secretion signal release negative regulation of hormone secretion negative regulation of secretion by cell regulation of signaling regulation of hormone levels regulation of gonadotropin secretion regulation of secretion endocrine hormone secretion endocrine process negative regulation of gonadotropin secretion hormone transport regulation of endocrine process regulation of cytoskeleton organization regulation of actin filament organization regulation of actin filament-based process actin cytoskeleton organization actin filament organization regulation of actin cytoskeleton organization actin filament-based process regulation of supramolecular fiber organization supramolecular fiber organization regulation of stem cell proliferation positive regulation of cell population proliferation positive regulation of stem cell proliferation stem cell proliferation embryo development ending in birth or egg hatching chordate embryonic development in utero embryonic development cell activation lymphocyte activation leukocyte proliferation leukocyte activation immune system process mononuclear cell proliferation T cell activation lymphocyte proliferation T cell proliferation morphogenesis of an epithelium positive regulation of morphogenesis of an epithelium regulation of morphogenesis of an epithelium regulation of anatomical structure morphogenesis cardiac conduction regulation of body fluid levels renal system process regulation of renal system process regulation of blood pressure regulation of glomerular filtration positive regulation of glomerular filtration regulation of systemic arterial blood pressure renal system process involved in regulation of blood volume renal system process involved in regulation of systemic arterial blood pressure glomerular filtration renal filtration endothelium development adult heart development regulation of bone remodeling bone remodeling regulation of tissue remodeling pattern specification process embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry epithelial tube morphogenesis embryonic organ development determination of left/right symmetry specification of symmetry embryonic organ morphogenesis determination of heart left/right asymmetry regionalization left/right pattern formation response to fluid shear stress osteoblast differentiation positive regulation of cytosolic calcium ion concentration response to peptide hormone regulation of DNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process negative regulation of DNA metabolic process DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process vascular transport monoatomic ion transmembrane transport regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation vascular associated smooth muscle cell proliferation reflex secretion by tissue mammary gland development gland development body fluid secretion milk ejection reflex lactation response to retinoic acid signal transduction cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis plasma membrane bounded cell projection organization nervous system development generation of neurons neuron development vasodilation homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis negative regulation of locomotion regulation of cell motility regulation of trophoblast cell migration ameboidal-type cell migration regulation of cell migration cell migration cell motility embryo implantation negative regulation of trophoblast cell migration locomotion negative regulation of cell migration trophoblast cell migration negative regulation of reproductive process regulation of locomotion negative regulation of cell motility neuron migration neuroblast migration establishment of protein localization positive regulation of establishment of protein localization positive regulation of insulin secretion regulation of peptide hormone secretion positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion regulation of protein secretion positive regulation of protein localization regulation of protein localization regulation of peptide secretion positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport peptide secretion positive regulation of hormone secretion positive regulation of secretion amide transport positive regulation of peptide secretion regulation of peptide transport regulation of establishment of protein localization regulation of protein transport positive regulation of protein secretion peptide transport positive regulation of transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion insulin secretion positive regulation of signaling	cell-cell junction anchoring junction cell junction cellular anatomical entity intracellular anatomical structure cytoplasm cytosol intercalated disc fascia adherens cell-cell contact zone intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cell-cell junction anchoring junction cell junction cellular anatomical entity intracellular anatomical structure cytoplasm cytosol intercalated disc fascia adherens cell-cell contact zone intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle membrane-bounded organelle Golgi membrane Golgi apparatus membrane intracellular membrane-bounded organelle endomembrane system bounding membrane of organelle organelle membrane protein-containing complex plasma membrane protein complex gap junction plasma membrane membrane protein complex cell periphery connexin complex intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle Golgi-associated vesicle membrane Golgi-associated vesicle vesicle apical part of cell plasma membrane region apical plasma membrane membrane microdomain membrane raft organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane endosome lateral plasma membrane tight junction late endosome mitochondrial membrane mitochondrion organelle outer membrane organelle envelope mitochondrial envelope mitochondrial outer membrane outer membrane polymeric cytoskeletal fiber intermediate filament cytoskeleton cytoskeleton intermediate filament multivesicular body early endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR034634	Connexin, C-terminal	Homologous Superfamily
A	IPR035091	Gap junction alpha-1 protein (Cx43), alpha helix domain superfamily	Homologous Superfamily
A	IPR013124	Gap junction alpha-1 protein (Cx43), C-terminal	Domain
A	IPR002261	Gap junction alpha-1 protein (Cx43)	Family
A	IPR017990	Connexin, conserved site	Conserved Site
A	IPR038359	Connexin, N-terminal domain superfamily	Homologous Superfamily
A	IPR000500	Connexin	Family
A	IPR019570	Gap junction protein, cysteine-rich domain	Domain
A	IPR013092	Connexin, N-terminal	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.