Annotations: 1P97

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1p97a1	Alpha and beta proteins (a+b)	Profilin-like	PYP-like sensor domain (PAS domain)	Hypoxia-inducible factor Hif2a, C-terminal domain	Hypoxia-inducible factor Hif2a, C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1p97a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Hypoxia-inducible factor Hif2a C-terminal domain	8026064	4001541	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PYP-like sensor domain (PAS domain)	8038443	3000471	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAS_11	e1p97A1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS_11	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14598	PAS domain (PAS_11)	PAS domain	This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6) [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Endothelial PAS domain protein 1	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity transcription coregulator binding transcription coactivator binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity	heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate multicellular organismal-level homeostasis chemical homeostasis homeostatic process multicellular organismal-level chemical homeostasis surfactant homeostasis developmental process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development muscle structure development cellular developmental process cell differentiation cellular process myoblast differentiation cell fate commitment myoblast fate commitment response to decreased oxygen levels cellular response to stimulus response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical response to oxygen levels response to abiotic stimulus animal organ development respiratory tube development lung development respiratory system development multicellular organismal-level iron ion homeostasis inorganic ion homeostasis monoatomic ion homeostasis monoatomic cation homeostasis placenta development chordate embryonic development embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development organonitrogen compound metabolic process regulation of protein modification process regulation of post-translational protein modification regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process regulation of primary metabolic process regulation of protein neddylation organic substance metabolic process macromolecule modification metabolic process protein metabolic process macromolecule metabolic process regulation of protein modification by small protein conjugation or removal protein modification process post-translational protein modification regulation of metabolic process protein neddylation protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of cellular process signaling signal transduction cell communication positive regulation of biological process adaptive thermogenesis positive regulation of metabolic process regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process blood vessel remodeling tissue remodeling organic hydroxy compound metabolic process catechol-containing compound metabolic process norepinephrine metabolic process organic cyclic compound metabolic process amine metabolic process catecholamine metabolic process phenol-containing compound metabolic process biogenic amine metabolic process mRNA transcription by RNA polymerase II cellular biosynthetic process RNA metabolic process mRNA transcription nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance biosynthetic process cellular metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process biosynthetic process organic cyclic compound biosynthetic process sensory perception of light stimulus sensory perception nervous system process visual perception hemopoiesis cell development erythrocyte differentiation myeloid cell differentiation immune system process homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of cellular metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription response to oxidative stress cellular component organization organelle organization cellular component organization or biogenesis mitochondrion organization positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process epithelium development developmental maturation tissue development epithelial cell differentiation epithelial cell development anatomical structure maturation epithelial cell maturation cell maturation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol protein-containing complex transcription regulator complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR021537	Hypoxia-inducible factor, alpha subunit-like	Domain
A	IPR014887	HIF-1 alpha, C-terminal transactivation domain	Domain
A	IPR013767	PAS fold	Domain
A	IPR001067	Nuclear translocator	Family
A	IPR000014	PAS domain	Domain
A	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
A	IPR035965	PAS domain superfamily	Homologous Superfamily
A	IPR001610	PAC motif	Repeat
A	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q99814	erythrocytosis, familial, 4 renal cell carcinoma familial polycythemia sarcomatoid renal cell carcinoma chromophobe renal cell carcinoma papillary renal cell carcinoma Chromosome Aberrations collecting duct carcinoma invasive ductal breast carcinoma lung cancer nasopharyngeal carcinoma acquired polycythemia vera oligodendroglioma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm erythrocytosis, familial, 4 renal cell carcinoma familial polycythemia sarcomatoid renal cell carcinoma chromophobe renal cell carcinoma papillary renal cell carcinoma Chromosome Aberrations collecting duct carcinoma invasive ductal breast carcinoma lung cancer nasopharyngeal carcinoma acquired polycythemia vera oligodendroglioma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor von Hippel-Lindau disease clear cell renal carcinoma ductal breast carcinoma in situ large cell medulloblastoma lung carcinoma MALT lymphoma adrenal cortex carcinoma osteosarcoma renal carcinoma breast carcinoma secondary polycythemia lung adenocarcinoma malignant mesothelioma medulloblastoma non-small cell lung carcinoma adrenal medulla cancer ovarian cancer benign neoplasm of adrenal gland polycythemia tuberculosis chronic obstructive pulmonary disease erythropoietin polycythemia

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.