1HN3

SOLUTION STRUCTURE OF THE N-TERMINAL 37 AMINO ACIDS OF THE MOUSE ARF TUMOR SUPPRESSOR PROTEIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1hn3a1	Peptides	Tumor suppressor protein p19-ARF fragment	Tumor suppressor protein p19-ARF fragment	Tumor suppressor protein p19-ARF fragment	Tumor suppressor protein p19-ARF fragment	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1hn3a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.250.60	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07392	Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus (P19Arf_N)	Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	P19 ARF PROTEIN	enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity molecular function regulator activity enzyme inhibitor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding NF-kappaB binding protein kinase regulator activity protein kinase inhibitor activity enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity molecular function regulator activity enzyme inhibitor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding NF-kappaB binding protein kinase regulator activity protein kinase inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity cyclin-dependent protein serine/threonine kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity SUMO transferase activity transferase activity catalytic activity DNA binding organic cyclic compound binding nucleic acid binding ubiquitin ligase inhibitor activity p53 binding MDM2/MDM4 family protein binding kinase binding enzyme binding protein kinase binding disordered domain specific binding protein domain specific binding	response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction signal transduction by p53 class mediator regulation of response to stimulus regulation of cell communication cellular process positive regulation of signaling negative regulation of lymphocyte proliferation multicellular organismal process regulation of leukocyte activation negative regulation of biological process regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte activation negative regulation of mononuclear cell proliferation negative regulation of leukocyte proliferation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation negative regulation of cellular process regulation of multicellular organismal process regulation of immune system process negative regulation of B cell activation regulation of lymphocyte proliferation regulation of leukocyte proliferation negative regulation of cell population proliferation cell population proliferation B cell activation cell activation B cell proliferation negative regulation of B cell proliferation negative regulation of cell activation negative regulation of immune system process regulation of cell population proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation negative regulation of post-translational protein modification regulation of protein modification process regulation of primary metabolic process organic substance metabolic process negative regulation of protein modification process protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process protein neddylation negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of protein neddylation organonitrogen compound metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process regulation of protein neddylation macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal ribonucleoprotein complex biogenesis regulation of ribosome biogenesis regulation of cellular component biogenesis cellular component biogenesis ribosome biogenesis negative regulation of ribosome biogenesis cellular component organization or biogenesis regulation of protein stability regulation of biological quality protein stabilization protein destabilization cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of cellular biosynthetic process catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process regulation of ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis negative regulation of ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process negative regulation of catabolic process regulation of catabolic process protein catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process positive regulation of DNA-binding transcription factor activity RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of molecular function organic cyclic compound metabolic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of DNA-templated transcription replicative senescence negative regulation of cell cycle cell cycle regulation of cell cycle positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death epithelial cell proliferation keratinocyte proliferation regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization nucleocytoplasmic transport transport nuclear transport localization cellular macromolecule localization establishment of localization in cell regulation of protein export from nucleus nuclear export regulation of intracellular transport regulation of transport organic substance transport regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport regulation of protein transport protein export from nucleus establishment of localization protein transport regulation of cellular localization macromolecule localization regulation of intracellular protein transport intracellular protein transport cellular response to stress response to stress cellular senescence protein targeting regulation of protein targeting to mitochondrion regulation of establishment of protein localization to mitochondrion establishment of protein localization to organelle regulation of protein targeting protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion protein polyubiquitination protein ubiquitination regulation of DNA catabolic process execution phase of apoptosis DNA catabolic process apoptotic nuclear changes regulation of apoptotic DNA fragmentation cellular component disassembly DNA metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process apoptotic DNA fragmentation cellular component disassembly involved in execution phase of apoptosis nucleic acid catabolic process regulation of DNA metabolic process regulation of cellular response to stress DNA damage response, signal transduction by p53 class mediator regulation of response to stress regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of DNA damage response, signal transduction by p53 class mediator DNA damage response signal transduction in response to DNA damage regulation of leukocyte differentiation negative regulation of T cell differentiation in thymus mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation negative regulation of T cell proliferation regulation of cell development negative regulation of cell adhesion T cell differentiation in thymus multicellular organism development negative regulation of T cell differentiation T cell activation cell differentiation anatomical structure development T cell differentiation regulation of immature T cell proliferation negative regulation of hemopoiesis developmental process negative regulation of immature T cell proliferation negative regulation of leukocyte differentiation regulation of immature T cell proliferation in thymus negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of lymphocyte differentiation leukocyte differentiation cellular developmental process regulation of developmental process immature T cell proliferation in thymus cell development regulation of T cell differentiation in thymus leukocyte cell-cell adhesion regulation of T cell differentiation cell adhesion cell-cell adhesion regulation of cell-cell adhesion negative regulation of cell differentiation negative regulation of immature T cell proliferation in thymus T cell proliferation regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis negative regulation of developmental process regulation of cell adhesion regulation of T cell activation immature T cell proliferation negative regulation of cell development regulation of T cell proliferation regulation of hemopoiesis rRNA transcription rRNA metabolic process cell cycle G2/M phase transition regulation of cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process G2/M transition of mitotic cell cycle regulation of cell cycle G2/M phase transition cell cycle phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle mitotic cell cycle process cell cycle process mitotic cell cycle phase transition somatic stem cell population maintenance maintenance of cell number stem cell population maintenance regulation of catalytic activity regulation of protein ubiquitination negative regulation of catalytic activity regulation of transferase activity negative regulation of ubiquitin-protein transferase activity negative regulation of transferase activity regulation of ubiquitin-protein transferase activity negative regulation of protein ubiquitination negative regulation of molecular function regulation of protein localization to nucleus negative regulation of protein localization to nucleolus protein localization to nucleus negative regulation of protein localization to nucleus protein localization to nucleolus negative regulation of protein localization regulation of protein localization to nucleolus transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process apoptotic process involved in morphogenesis mammary gland morphogenesis apoptotic process involved in mammary gland involution mammary gland development gland development animal organ development apoptotic process involved in development anatomical structure morphogenesis gland morphogenesis tissue remodeling mammary gland involution animal organ morphogenesis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of biosynthetic process epithelium development epidermal cell differentiation epidermis development tissue development epithelial cell differentiation skin development keratinocyte differentiation positive regulation of protein localization to nucleus positive regulation of protein localization regulation of protein sumoylation positive regulation of protein metabolic process peptidyl-lysine modification positive regulation of post-translational protein modification positive regulation of protein modification process peptidyl-amino acid modification positive regulation of protein modification by small protein conjugation or removal protein sumoylation positive regulation of protein sumoylation organelle organization apoptotic mitochondrial changes mitochondrion organization response to organic substance response to organonitrogen compound response to nitrogen compound amyloid fibril formation supramolecular fiber organization rRNA processing RNA processing negative regulation of mammary gland epithelial cell proliferation regulation of mammary gland epithelial cell proliferation mammary gland epithelium development regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation mammary gland epithelial cell proliferation regulation of hepatocyte proliferation liver development liver morphogenesis system development epithelial cell proliferation involved in liver morphogenesis hepatocyte proliferation hepaticobiliary system development negative regulation of hepatocyte proliferation phosphorylation negative regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of phosphorus metabolic process regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation phosphorus metabolic process cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to inorganic substance response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to chemical stimulus regulation of mitochondrial membrane potential membrane depolarization mitochondrial depolarization regulation of membrane potential oncogene-induced cell senescence protein K63-linked ubiquitination regulation of cell-substrate adhesion cell-substrate adhesion negative regulation of cell-matrix adhesion cell-matrix adhesion regulation of cell-matrix adhesion negative regulation of cell-substrate adhesion nuclear body organization nucleus organization somatic stem cell division stem cell division cell division regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle response to organic cyclic compound positive regulation of apoptotic process involved in mammary gland involution positive regulation of developmental process positive regulation of apoptotic process involved in morphogenesis positive regulation of apoptotic process involved in development regulation of apoptotic process involved in development regulation of apoptotic process involved in morphogenesis	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle granular component protein-containing complex protein-DNA complex chromatin chromosome senescence-associated heterochromatin focus heterochromatin nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR010868	Tumor suppressor ARF	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.