Annotations: 6UQK

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	Ins145_P3_rec	e6uqkD3	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ins145_P3_rec	ECOD (1.6)
D	MIR	e6uqkD6	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: MIR	ECOD (1.6)
D	RIH_assoc	e6uqkD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RIH_assoc	ECOD (1.6)
D	KOG3533	e6uqkD4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG3533	ECOD (1.6)
D	RYDR_ITPR_1	e6uqkD5	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RYDR_ITPR_1	ECOD (1.6)
D	RYDR_ITPR_2	e6uqkD2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RYDR_ITPR_2	ECOD (1.6)
D	RR_TM4-6	e6uqkD7	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: RR_TM4-6	ECOD (1.6)
A	Ins145_P3_rec	e6uqkA3	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ins145_P3_rec	ECOD (1.6)
A	MIR	e6uqkA6	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: MIR	ECOD (1.6)
A	RIH_assoc	e6uqkA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RIH_assoc	ECOD (1.6)
A	KOG3533	e6uqkA4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG3533	ECOD (1.6)
A	RYDR_ITPR_1	e6uqkA5	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RYDR_ITPR_1	ECOD (1.6)
A	RYDR_ITPR_2	e6uqkA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RYDR_ITPR_2	ECOD (1.6)
A	RR_TM4-6	e6uqkA7	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: RR_TM4-6	ECOD (1.6)
B	Ins145_P3_rec	e6uqkB3	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ins145_P3_rec	ECOD (1.6)
B	MIR	e6uqkB6	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: MIR	ECOD (1.6)
B	RIH_assoc	e6uqkB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RIH_assoc	ECOD (1.6)
B	KOG3533	e6uqkB4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG3533	ECOD (1.6)
B	RYDR_ITPR_1	e6uqkB5	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RYDR_ITPR_1	ECOD (1.6)
B	RYDR_ITPR_2	e6uqkB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RYDR_ITPR_2	ECOD (1.6)
B	RR_TM4-6	e6uqkB7	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: RR_TM4-6	ECOD (1.6)
C	Ins145_P3_rec	e6uqkC3	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ins145_P3_rec	ECOD (1.6)
C	MIR	e6uqkC6	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: MIR	ECOD (1.6)
C	RIH_assoc	e6uqkC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RIH_assoc	ECOD (1.6)
C	KOG3533	e6uqkC4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG3533	ECOD (1.6)
C	RYDR_ITPR_1	e6uqkC5	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RYDR_ITPR_1	ECOD (1.6)
C	RYDR_ITPR_2	e6uqkC2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: RYDR_ITPR_2	ECOD (1.6)
C	RR_TM4-6	e6uqkC7	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: RR_TM4-6	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08454	RyR and IP3R Homology associated (RIH_assoc)	RyR and IP3R Homology associated	-	Repeat
A, B, C, D	PF02815	MIR domain (MIR)	MIR domain	The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function [1].	Domain
A, B, C, D	PF08709	Inositol 1,4,5-trisphosphate/ryanodine receptor (Ins145_P3_rec)	Inositol 1,4,5-trisphosphate/ryanodine receptor	This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-ga ...	This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity [1].	Domain
A, B, C, D	PF01365	RIH domain (RYDR_ITPR)	RIH domain	-	Repeat
A, B, C, D	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	inositol 1,4,5-triphosphate receptor, type 3	binding phospholipid binding lipid binding phosphatidylinositol binding cation binding ion binding calcium ion binding metal ion binding small molecule binding calcium channel activity monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity binding phospholipid binding lipid binding phosphatidylinositol binding cation binding ion binding calcium ion binding metal ion binding small molecule binding calcium channel activity monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity intracellularly gated calcium channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity ligand-gated calcium channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity inositol hexakisphosphate binding alcohol binding anion binding inositol 1,3,4,5 tetrakisphosphate binding inositol 1,4,5 trisphosphate binding inositol 1,4,5-trisphosphate-gated calcium channel activity	positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality response to stimulus response to metal ion response to chemical response to calcium ion response to inorganic substance multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality response to stimulus response to metal ion response to chemical response to calcium ion response to inorganic substance multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste behavior learning or memory cognition memory sensory perception of bitter taste sensory perception of sweet taste inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis sensory perception of umami taste regulation of localization cellular localization regulation of cellular process intracellular calcium ion homeostasis transport monoatomic ion transmembrane transport negative regulation of biological process negative regulation of sequestering of calcium ion calcium ion transport metal ion transport maintenance of location in cell monoatomic cation transmembrane transport localization intracellular monoatomic cation homeostasis negative regulation of cellular process monoatomic ion transport intracellular chemical homeostasis monoatomic cation transport regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis regulation of biological process calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol cellular homeostasis cellular process calcium ion transmembrane transport cellular response to stimulus signaling G protein-coupled receptor signaling pathway signal transduction cell communication positive regulation of cell communication modulation of chemical synaptic transmission positive regulation of biological process long-term synaptic potentiation synaptic signaling positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of signaling cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication positive regulation of signaling	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane myelin sheath apical part of cell cell periphery plasma membrane cluster of actin-based cell projections brush border cytoplasm nucleoplasm organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane protein-containing complex receptor complex platelet dense tubular network platelet dense tubular network membrane bounding membrane of organelle cytoplasmic side of membrane side of membrane cytoplasmic side of endoplasmic reticulum membrane nuclear outer membrane nuclear membrane organelle outer membrane organelle envelope nuclear envelope outer membrane intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle vesicle secretory granule membrane sarcoplasm sarcoplasmic reticulum somatodendritic compartment cell body neuronal cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036300	Mir domain superfamily	Homologous Superfamily
A, B, C, D	IPR000699	RIH domain	Domain
A, B, C, D	IPR013662	RyR/IP3R Homology associated domain	Domain
A, B, C, D	IPR016093	MIR motif	Domain
A, B, C, D	IPR014821	Inositol 1,4,5-trisphosphate/ryanodine receptor	Domain
A, B, C, D	IPR000493	Inositol 1,4,5-trisphosphate receptor	Family
A, B, C, D	IPR005821	Ion transport domain	Domain
A, B, C, D	IPR015925	Ryanodine/Inositol 1,4,5-trisphosphate receptor	Family
A, B, C, D	IPR035910	RyR/IP3 receptor binding core, RIH domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q14573	type 1 diabetes mellitus acrodermatitis pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis testicular germ cell tumor acquired metabolic disease B-cell chronic lymphocytic leukemia Crohn disease Diabetes, Autoimmune Graves disease lung adenocarcinoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma type 1 diabetes mellitus acrodermatitis pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis testicular germ cell tumor acquired metabolic disease B-cell chronic lymphocytic leukemia Crohn disease Diabetes, Autoimmune Graves disease lung adenocarcinoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma subependymal giant cell astrocytoma Barrett esophagus esophageal adenocarcinoma Hodgkins lymphoma lung cancer ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer testicular cancer autism spectrum disorder IDDM 1 malignant pancreatic neoplasm

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Calcium Ion-Selective	InsP₃R3 Inositol-1,4,5-trisphosphate receptor and presence of self-binding peptide