6DU2

Structure of Scp1 D96N bound to REST-pS861/4 peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	NLI interacting factor-like phosphatase	8101228	4002095	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HAD-like	8101229	3001890	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	HAD-like	8101229	3001890	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	NIF	e6du2A1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: NIF	ECOD (1.6)
B	NIF	e6du2B1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: NIF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
B	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03031	NLI interacting factor-like phosphatase (NIF)	NLI interacting factor-like phosphatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X2	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds myosin phosphatase activity phosphatase activity hydrolase activity catalytic activity RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat phosphatase activity	-	-
C, D	REST-pS861/4	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cation binding ion binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation inner ear development animal organ morphogenesis embryonic organ morphogenesis mechanoreceptor differentiation epithelium development epidermal cell differentiation ear development embryonic morphogenesis tissue development inner ear receptor cell differentiation auditory receptor cell development cell development embryo development cell morphogenesis cellular component organization cellular component organization or biogenesis auditory receptor cell morphogenesis embryonic organ development ear morphogenesis plasma membrane bounded cell projection organization animal organ development inner ear auditory receptor cell differentiation cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis sensory organ morphogenesis neuron development inner ear morphogenesis inner ear receptor cell stereocilium organization cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process response to stimulus response to stress response to ischemia negative regulation of stem cell differentiation negative regulation of mesenchymal stem cell differentiation stem cell differentiation mesenchymal stem cell differentiation regulation of stem cell differentiation regulation of mesenchymal stem cell differentiation positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death regulation of localization regulated exocytosis transport regulation of calcium ion-dependent exocytosis negative regulation of transport negative regulation of regulated secretory pathway vesicle-mediated transport regulation of regulated secretory pathway localization secretion by cell regulation of secretion by cell negative regulation of secretion negative regulation of exocytosis negative regulation of secretion by cell calcium-ion regulated exocytosis secretion regulation of transport negative regulation of calcium ion-dependent exocytosis export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion exocytosis regulation of exocytosis RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus somatic stem cell population maintenance maintenance of cell number stem cell population maintenance cellular response to stimulus cellular response to chemical stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus regulation of neurogenesis regulation of cell development regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development regulation of multicellular organismal process regulation of multicellular organismal development negative regulation of cell development negative regulation of multicellular organismal process response to electrical stimulus cellular response to electrical stimulus cellular response to abiotic stimulus cellular response to environmental stimulus negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process neuronal stem cell population maintenance amniotic stem cell differentiation negative regulation of amniotic stem cell differentiation regulation of amniotic stem cell differentiation regulation of osteoblast differentiation osteoblast differentiation ossification viral gene expression biological process involved in interspecies interaction between organisms negative regulation by host of viral transcription modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription biological process involved in symbiotic interaction regulation of dense core granule biogenesis regulation of cellular component biogenesis negative regulation of dense core granule biogenesis cellular component biogenesis dense core granule biogenesis negative regulation of small molecule metabolic process regulation of hormone biosynthetic process regulation of lipid metabolic process negative regulation of lipid biosynthetic process negative regulation of hormone biosynthetic process cellular ketone metabolic process regulation of small molecule metabolic process negative regulation of aldosterone biosynthetic process negative regulation of aldosterone metabolic process small molecule metabolic process regulation of biological quality primary alcohol biosynthetic process hormone biosynthetic process negative regulation of steroid hormone biosynthetic process regulation of steroid hormone biosynthetic process negative regulation of steroid metabolic process regulation of cellular ketone metabolic process regulation of alcohol biosynthetic process olefinic compound biosynthetic process regulation of hormone levels C21-steroid hormone biosynthetic process negative regulation of alcohol biosynthetic process regulation of aldosterone biosynthetic process negative regulation of hormone metabolic process negative regulation of lipid metabolic process regulation of steroid biosynthetic process mineralocorticoid biosynthetic process regulation of hormone metabolic process steroid metabolic process organic hydroxy compound metabolic process lipid biosynthetic process alcohol metabolic process C21-steroid hormone metabolic process aldehyde biosynthetic process mineralocorticoid metabolic process aldosterone metabolic process cellular aldehyde metabolic process steroid biosynthetic process steroid hormone biosynthetic process small molecule biosynthetic process aldosterone biosynthetic process regulation of ketone biosynthetic process regulation of steroid metabolic process hormone metabolic process regulation of aldosterone metabolic process organic hydroxy compound biosynthetic process alcohol biosynthetic process negative regulation of steroid biosynthetic process olefinic compound metabolic process regulation of lipid biosynthetic process ketone biosynthetic process lipid metabolic process primary alcohol metabolic process alternative mRNA splicing, via spliceosome regulation of mRNA splicing, via spliceosome mRNA processing RNA processing regulation of mRNA processing RNA splicing regulation of RNA splicing mRNA metabolic process RNA splicing, via transesterification reactions regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of mRNA metabolic process regulation of stem cell population maintenance positive regulation of developmental process positive regulation of stem cell population maintenance positive regulation of multicellular organismal process system process nervous system process neuromuscular process neuromuscular process controlling balance regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of molecular function regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity protein metabolic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis protein localization negative regulation of protein transport establishment of protein localization nitrogen compound transport cell communication cellular macromolecule localization negative regulation of hormone secretion regulation of peptide hormone secretion negative regulation of peptide hormone secretion organic substance transport establishment of protein localization to extracellular region negative regulation of establishment of protein localization protein secretion regulation of protein secretion negative regulation of protein secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion signaling negative regulation of signaling hormone secretion negative regulation of cell communication protein localization to extracellular region negative regulation of peptide secretion peptide secretion amide transport signal release negative regulation of protein localization regulation of signaling regulation of peptide transport regulation of establishment of protein localization cell-cell signaling regulation of protein transport peptide transport negative regulation of insulin secretion protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion negative regulation of miRNA transcription regulation of miRNA metabolic process miRNA metabolic process miRNA transcription ncRNA metabolic process negative regulation of miRNA metabolic process regulation of miRNA transcription detection of external stimulus detection of mechanical stimulus involved in sensory perception of sound response to mechanical stimulus response to external stimulus detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of mechanical stimulus detection of stimulus involved in sensory perception sensory perception of sound positive regulation of neuron differentiation positive regulation of cell differentiation negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of DNA binding regulation of binding negative regulation of binding negative regulation of transcription regulatory region DNA binding negative regulation of molecular function regulation of transcription regulatory region DNA binding negative regulation of DNA binding heart development cardiac muscle cell myoblast differentiation cardiocyte differentiation circulatory system development muscle structure development cardioblast differentiation myoblast differentiation cell junction organization synapse organization modification of synaptic structure cortisol metabolic process tertiary alcohol metabolic process glucocorticoid metabolic process glucocorticoid biosynthetic process regulation of cortisol biosynthetic process negative regulation of cortisol biosynthetic process regulation of glucocorticoid metabolic process regulation of glucocorticoid biosynthetic process negative regulation of glucocorticoid biosynthetic process negative regulation of glucocorticoid metabolic process cortisol biosynthetic process tertiary alcohol biosynthetic process hemopoiesis hematopoietic progenitor cell differentiation negative regulation of gene expression response to organic substance response to lipid response to endogenous stimulus response to glucocorticoid cellular response to organic cyclic compound cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus cellular response to endogenous stimulus response to corticosteroid response to hormone response to steroid hormone cellular response to lipid cellular response to organic substance cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus protein-DNA complex organization protein-containing complex organization chromatin organization chromatin remodeling	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex transcription regulator complex transcription repressor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004274	FCP1 homology domain	Domain
A, B	IPR040078	CTD small RNA polymerase II polypeptide A phosphatase-like	Family
A, B	IPR036412	HAD-like superfamily	Homologous Superfamily
A, B	IPR023214	HAD superfamily	Homologous Superfamily
A, B	IPR011948	Dullard phosphatase domain, eukaryotic	Domain
C, D	IPR013087	Zinc finger C2H2-type	Domain
C, D	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C, D	Pharos: Q13127	kidney Wilms tumor visual epilepsy Wilms tumor 6 hereditary gingival fibromatosis lung carcinoma malignant glioma Absence Seizures attention deficit hyperactivity disorder, inattentive type breast cancer Perlman syndrome schizophrenia hereditary Wilms tumor large cell medulloblastoma major depressive disorder myocardial infarction kidney Wilms tumor visual epilepsy Wilms tumor 6 hereditary gingival fibromatosis lung carcinoma malignant glioma Absence Seizures attention deficit hyperactivity disorder, inattentive type breast cancer Perlman syndrome schizophrenia hereditary Wilms tumor large cell medulloblastoma major depressive disorder myocardial infarction age-related macular degeneration atypical teratoid rhabdoid tumor ovarian cancer pilocytic astrocytoma cutaneous lupus erythematosus fetal alcohol syndrome heart disease lung cancer malignant ependymoma nonsyndromic genetic deafness pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor fibromatosis, gingival, 5 glioblastoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C, D	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.