6DRF

Structure of human Retinal Degeneration 3(RD3) Protein

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF14473	e6drfA1	A: alpha bundles	X: Helical domain of retinal degeneration 3 protein (From Topology)	H: Helical domain of retinal degeneration 3 protein (From Topology)	T: Helical domain of retinal degeneration 3 protein	F: PF14473	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14473	RD3 protein (RD3)	RD3 protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein RD3	-	regulation of cellular process negative regulation of small molecule metabolic process regulation of catalytic activity nucleotide biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of catalytic activity regulation of nucleotide biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of lyase activity negative regulation of nucleotide metabolic process regulation of small molecule metabolic process negative regulation of nucleotide biosynthetic process regulation of cellular process negative regulation of small molecule metabolic process regulation of catalytic activity nucleotide biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of catalytic activity regulation of nucleotide biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of lyase activity negative regulation of nucleotide metabolic process regulation of small molecule metabolic process negative regulation of nucleotide biosynthetic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process phosphorus metabolic process nucleoside phosphate metabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process regulation of molecular function organic cyclic compound metabolic process negative regulation of lyase activity biosynthetic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process regulation of phosphorus metabolic process regulation of metabolic process purine nucleotide biosynthetic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process negative regulation of guanylate cyclase activity regulation of guanylate cyclase activity purine nucleotide metabolic process organic substance metabolic process negative regulation of purine nucleotide biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process negative regulation of cellular process regulation of cyclase activity regulation of biosynthetic process regulation of purine nucleotide biosynthetic process organonitrogen compound metabolic process biological regulation negative regulation of molecular function nucleobase-containing compound biosynthetic process purine-containing compound metabolic process organophosphate metabolic process negative regulation of biosynthetic process negative regulation of phosphorus metabolic process negative regulation of cyclase activity cellular process developmental process multicellular organismal process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development system development sensory perception of light stimulus system process sensory perception nervous system process visual perception protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization response to stimulus	photoreceptor inner segment cellular anatomical entity membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle non-motile cilium photoreceptor inner segment cellular anatomical entity membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle non-motile cilium 9+0 non-motile cilium cilium neuron projection photoreceptor outer segment plasma membrane bounded cell projection cell projection photoreceptor cell cilium cone photoreceptor outer segment perinuclear region of cytoplasm rod photoreceptor outer segment nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR028092	Retinal degeneration protein 3	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q7Z3Z2	Leber congenital amaurosis Leber congenital amaurosis 12 large cell medulloblastoma LEBER CONGENITAL AMAUROSIS 12 (disorder) pituitary cancer lung carcinoma medulloblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.