Annotations: 6D7L

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08344	e6d7lA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF08344	ECOD (1.6)
B	PF08344	e6d7lB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF08344	ECOD (1.6)
C	PF08344	e6d7lC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF08344	ECOD (1.6)
D	PF08344	e6d7lD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF08344	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08344	Transient receptor ion channel II (TRP_2)	Transient receptor ion channel II	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Short transient receptor potential channel 3	calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity store-operated calcium channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity store-operated calcium channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity calcium-activated cation channel activity gated channel activity monoatomic ion-gated channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity ligand-gated monoatomic cation channel activity binding ion binding alcohol binding inositol 1,4,5 trisphosphate binding anion binding small molecule binding cation binding metal ion binding	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport response to stimulus response to metal ion response to chemical response to calcium ion response to inorganic substance response to organic substance response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to ATP response to purine-containing compound response to organic cyclic compound regulation of localization regulation of calcium ion transport positive regulation of cation transmembrane transport positive regulation of calcium ion transport cellular localization regulation of cellular process regulation of calcium ion transport into cytosol positive regulation of biological process regulation of monoatomic ion transmembrane transport regulation of calcium ion transmembrane transport positive regulation of monoatomic ion transport positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport positive regulation of monoatomic ion transmembrane transport regulation of biological quality regulation of metal ion transport positive regulation of cellular process regulation of biological process calcium ion transmembrane import into cytosol regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport into cytosol regulation of transmembrane transport positive regulation of transport regulation of cellular localization regulation of monoatomic cation transmembrane transport calcium ion transport into cytosol phototransduction cellular response to stimulus detection of light stimulus response to light stimulus detection of external stimulus signaling response to external stimulus detection of abiotic stimulus cell communication detection of stimulus response to abiotic stimulus response to radiation signal transduction sexual reproduction reproductive process fertilization single fertilization multicellular organismal process system process striated muscle adaptation positive regulation of cardiac muscle hypertrophy regulation of system process positive regulation of cardiac muscle hypertrophy in response to stress regulation of muscle hypertrophy positive regulation of response to stimulus regulation of cardiac muscle hypertrophy in response to stress muscle adaptation cardiac muscle adaptation regulation of response to stress response to stress cardiac muscle hypertrophy positive regulation of muscle adaptation regulation of multicellular organismal process cardiac muscle hypertrophy in response to stress muscle hypertrophy regulation of muscle adaptation striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of response to stimulus positive regulation of cardiac muscle adaptation positive regulation of muscle hypertrophy positive regulation of multicellular organismal process regulation of cardiac muscle adaptation muscle hypertrophy in response to stress inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis	cell periphery plasma membrane membrane cellular anatomical entity protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR002110	Ankyrin repeat	Repeat
A, B, C, D	IPR005821	Ion transport domain	Domain
A, B, C, D	IPR005459	Transient receptor potential channel, canonical 3	Family
A, B, C, D	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR002153	Transient receptor potential channel, canonical	Family
A, B, C, D	IPR013555	Transient receptor ion channel domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q13507	spinocerebellar ataxia type 41 autosomal dominant cerebellar ataxia bipolar disorder hypertensive disorder osteosarcoma spinocerebellar ataxia type 1 spinocerebellar ataxia type 7 Acne vulgaris atypical teratoid rhabdoid tumor cerebellar ataxia glioblastoma lung cancer postmenopausal osteoporosis spinocerebellar ataxia type 2 spinocerebellar ataxia type 5 spinocerebellar ataxia type 41 autosomal dominant cerebellar ataxia bipolar disorder hypertensive disorder osteosarcoma spinocerebellar ataxia type 1 spinocerebellar ataxia type 7 Acne vulgaris atypical teratoid rhabdoid tumor cerebellar ataxia glioblastoma lung cancer postmenopausal osteoporosis spinocerebellar ataxia type 2 spinocerebellar ataxia type 5 hereditary ataxia malignant ependymoma neurodegenerative disease psoriasis spinocerebellar ataxia type 4 spinocerebellar ataxia type 6 malignant glioma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.