6B9J

Structure of vaccinia virus D8 protein bound to human Fab vv138

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D [auth Y]	d6b9jy1	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	(Vaccinia virus ) [TaxId: 10245 ],	SCOPe (2.08)
D [auth Y]	d6b9jy2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Vaccinia virus ) [TaxId: 10245 ],	SCOPe (2.08)
A [auth X]	d6b9jx1	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	(Vaccinia virus ) [TaxId: 10245 ],	SCOPe (2.08)
A [auth X]	d6b9jx2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Vaccinia virus ) [TaxId: 10245 ],	SCOPe (2.08)
B [auth H]	d6b9jh_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth A]	d6b9ja_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth L]	d6b9jl1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth L]	d6b9jl2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth B]	d6b9jb1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth B]	d6b9jb2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth Y]	SCOP2B Superfamily	Carbonic anhydrase	8065133	3001672	SCOP2B (2022-06-29)
A [auth X]	SCOP2 Family	Carbonic anhydrase	8065132	4002732	SCOP2 (2022-06-29)
A [auth X]	SCOP2 Superfamily	Carbonic anhydrase	8065133	3001672	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth Y]	Carb_anhydrase	e6b9jY1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
A [auth X]	Carb_anhydrase	e6b9jX1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
B [auth H]	V-set_8	e6b9jH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
B [auth H]	C1-set_1	e6b9jH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
E [auth A]	V-set_8	e6b9jA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
E [auth A]	C1-set_1	e6b9jA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
C [auth L]	C1-set_4	e6b9jL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
C [auth L]	V-set	e6b9jL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
F [auth B]	C1-set_4	e6b9jB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
F [auth B]	V-set	e6b9jB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D [auth Y]	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
A [auth X]	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
B [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E [auth A]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F [auth B]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B [auth H], E [auth A]	Fab vv138	VH-CH1	Homo sapiens (human)	IGHV1-69-201, IGHJ101, IGHJ501, IGHJ502, IGHJ301, IGHJ302, IGHJ201, IGHG101, IGHG102, IGHG104, IGHG1*05	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202415-0)
C [auth L], F [auth B]	Fab vv138	L-KAPPA	Homo sapiens (human)	IGKV3-2001, IGKJ401, IGKC*01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth H], E [auth A]	Heavy Chain	IGHV1	-	imv membrane protein	SAbDab (2024-04-19)
C [auth L], F [auth B]	Light Chain	IGKV3	Kappa	imv membrane protein	SAbDab (2024-04-19)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X], D [auth Y]	PF00194	Eukaryotic-type carbonic anhydrase (Carb_anhydrase)	Eukaryotic-type carbonic anhydrase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X], D [auth Y]	IMV membrane protein	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding carbonate dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity	-	membrane cellular anatomical entity virion component virion membrane
B [auth H], E [auth A]	Fab vv138 Heavy chain	-	-	-
C [auth L], F [auth B]	Fab vv138 Light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X], D [auth Y]	IPR001148	Alpha carbonic anhydrase domain	Domain
A [auth X], D [auth Y]	IPR036398	Alpha carbonic anhydrase domain superfamily	Homologous Superfamily
A [auth X], D [auth Y]	IPR023561	Carbonic anhydrase, alpha-class	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.