Annotations: 5NGL

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17189	e5nglA2	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: PF17189	ECOD (1.6)
A	PF02055	e5nglA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF02055	ECOD (1.6)
B	PF17189	e5nglB2	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: PF17189	ECOD (1.6)
B	PF02055	e5nglB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF02055	ECOD (1.6)
C	PF17189	e5nglC1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: PF17189	ECOD (1.6)
C	PF02055	e5nglC2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF02055	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF17189	Glycosyl hydrolase family 30 beta sandwich domain (Glyco_hydro_30C)	Glycosyl hydrolase family 30 beta sandwich domain	-	Domain
A, B, C	PF02055	Glycosyl hydrolase family 30 TIM-barrel domain (Glyco_hydro_30)	Glycosyl hydrolase family 30 TIM-barrel domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Glucosylceramidase	glucosylceramidase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity	sphingolipid catabolic process catabolic process glycolipid metabolic process carbohydrate derivative metabolic process cellular lipid catabolic process cellular catabolic process organic substance metabolic process ceramide catabolic process amide metabolic process glycosylceramide metabolic process membrane lipid metabolic process organonitrogen compound catabolic process ceramide metabolic process carbohydrate derivative catabolic process sphingolipid catabolic process catabolic process glycolipid metabolic process carbohydrate derivative metabolic process cellular lipid catabolic process cellular catabolic process organic substance metabolic process ceramide catabolic process amide metabolic process glycosylceramide metabolic process membrane lipid metabolic process organonitrogen compound catabolic process ceramide metabolic process carbohydrate derivative catabolic process glycosphingolipid catabolic process lipid catabolic process organonitrogen compound metabolic process glycosphingolipid metabolic process cellular metabolic process liposaccharide metabolic process primary metabolic process sphingolipid metabolic process glucosylceramide metabolic process membrane lipid catabolic process glycosylceramide catabolic process glycolipid catabolic process cellular lipid metabolic process metabolic process cellular process glucosylceramide catabolic process organic substance catabolic process lipid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR033452	Glycosyl hydrolase family 30, beta sandwich domain	Domain
A, B, C	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B, C	IPR001139	Glycoside hydrolase family 30	Family
A, B, C	IPR013780	Glycosyl hydrolase, all-beta	Homologous Superfamily
A, B, C	IPR033453	Glycosyl hydrolase family 30, TIM-barrel domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.