Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADUF4111e5lpaA1 A: alpha arraysX: Aminoglycoside adenyltransferase AadA C-terminal domain (From Topology)H: Aminoglycoside adenyltransferase AadA C-terminal domain (From Topology)T: Aminoglycoside adenyltransferase AadA C-terminal domainF: DUF4111ECOD (1.6)
ANTP_transf_2e5lpaA2 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NTP_transf_2ECOD (1.6)
BDUF4111e5lpaB2 A: alpha arraysX: Aminoglycoside adenyltransferase AadA C-terminal domain (From Topology)H: Aminoglycoside adenyltransferase AadA C-terminal domain (From Topology)T: Aminoglycoside adenyltransferase AadA C-terminal domainF: DUF4111ECOD (1.6)
BNTP_transf_2e5lpaB1 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NTP_transf_2ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF13427Aminoglycoside adenylyltransferase, C-terminal domain (AadA_C)Aminoglycoside adenylyltransferase, C-terminal domainThis domain is found at the C-terminal end of Aminoglycoside adenylyltransferase from Salmonella typhimurium (AadA) and other proteins associated with methicillin-resistant bacteria. AadA adenylates the 3''-hydroxyl group of the streptomycin glucosam ...This domain is found at the C-terminal end of Aminoglycoside adenylyltransferase from Salmonella typhimurium (AadA) and other proteins associated with methicillin-resistant bacteria. AadA adenylates the 3''-hydroxyl group of the streptomycin glucosamine ring and the 9-hydroxyl group of the spectinomycin actinamine ring, mediating bacterial resistance to these antibiotics. This enzyme is organised into two domains: a N-terminal domain with a nucleotidyltransferase fold (Pfam:PF01909) and a C-terminal domain (this entry) which consists of five alpha-helices forming an up-and-down alpha-helical bundle. This domain undergoes small conformational changes upon binding of ATP and magnesium that play a key role in the binding of the antibiotic compounds [1,2].
Domain
A, B
PF01909Nucleotidyltransferase domain (NTP_transf_2)Nucleotidyltransferase domainMembers of this family belong to a large family of nucleotidyltransferases [1]. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTa ...Members of this family belong to a large family of nucleotidyltransferases [1]. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.
Domain