Annotations: 5AC8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5ac8a_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Salmonella enterica ) [TaxId: 28901 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8077809	3000216	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	His_biosynth	e5ac8A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: His_biosynth	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00977	Histidine biosynthesis protein (His_biosynth)	Histidine biosynthesis protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity catalytic activity	oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process organic substance metabolic process tryptophan biosynthetic process indole-containing compound biosynthetic process organic substance biosynthetic process indolalkylamine metabolic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process organic substance metabolic process tryptophan biosynthetic process indole-containing compound biosynthetic process organic substance biosynthetic process indolalkylamine metabolic process small molecule metabolic process indolalkylamine biosynthetic process organonitrogen compound metabolic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process tryptophan metabolic process organic cyclic compound metabolic process amine metabolic process amino acid biosynthetic process biosynthetic process amine biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process biogenic amine metabolic process alpha-amino acid biosynthetic process histidine metabolic process histidine biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR006063	HisA, bacterial-type	Family
A	IPR011060	Ribulose-phosphate binding barrel	Homologous Superfamily
A	IPR044524	Histidine biosynthesis, HisA-like	Family
A	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A	IPR006062	Histidine biosynthesis protein	Family
A	IPR023016	HisA/PriA, bacterial-type	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.