4ZMH

Crystal structure of a five-domain GH115 alpha-Glucuronidase from the Marine Bacterium Saccharophagus degradans 2-40T

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	GH115 postcatalytic domain-like	8053420	4007607	SCOP2 (2022-06-29)
A	SCOP2 Family	GH115 N-terminal domain-like	8053418	4007606	SCOP2 (2022-06-29)
A	SCOP2 Family	GH115 catalytic domain-like	8044836	4004167	SCOP2 (2022-06-29)
A	SCOP2 Family	GH115 alpha-Glucuronidase Sde_1755 postcatalytic domain-like	8053424	4007608	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	galactose-binding domain-like	8053421	3000087	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	beta-N-acetylhexosaminidase-like domain	8053419	3000192	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	(Trans)glycosidases	8053417	3000313	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PapD-like	8053425	3002067	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	galactose-binding domain-like	8053421	3000087	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	beta-N-acetylhexosaminidase-like domain	8053419	3000192	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	(Trans)glycosidases	8053417	3000313	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PapD-like	8053425	3002067	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CBM6_cellulase-like	e4zmhA3	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: CBM6_cellulase-like	ECOD (1.6)
A	Glyco_hydro_115	e4zmhA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_115	ECOD (1.6)
A	Glyco_hydro_67N	e4zmhA2	A: mixed a+b and a/b	X: Zincin-like	H: beta-N-acetylhexosaminidase-like domain (From Topology)	T: beta-N-acetylhexosaminidase-like domain	F: Glyco_hydro_67N	ECOD (1.6)
B	CBM6_cellulase-like	e4zmhB3	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: CBM6_cellulase-like	ECOD (1.6)
B	Glyco_hydro_115	e4zmhB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_115	ECOD (1.6)
B	Glyco_hydro_67N	e4zmhB2	A: mixed a+b and a/b	X: Zincin-like	H: beta-N-acetylhexosaminidase-like domain (From Topology)	T: beta-N-acetylhexosaminidase-like domain	F: Glyco_hydro_67N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.379.10	Alpha Beta	2-Layer Sandwich	Chitobiase	domain 2	CATH (4.3.0)
A	3.20.20.520	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosyl hydrolase family 115	CATH (4.3.0)
B	3.30.379.10	Alpha Beta	2-Layer Sandwich	Chitobiase	domain 2	CATH (4.3.0)
B	3.20.20.520	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosyl hydrolase family 115	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF15979	Glycosyl hydrolase family 115 (Glyco_hydro_115)	Glycosyl hydrolase family 115	-	Family
A, B	PF17829	Gylcosyl hydrolase family 115 C-terminal domain (GH115_C)	Gylcosyl hydrolase family 115 C-terminal domain	This domain is found at the C-terminus of glycosyl hydrolase family 115 proteins [1]. This domain has a beta-sandwich fold [1].	Domain
A, B	PF19190	Viral BACON domain (BACON_2)	Viral BACON domain	This family represents a distinct class of BACON domains found in crAss-like phages, the most common viral family in the human gut, in which they are found in tail fiber genes. This suggests they may play a role in phage-host interactions.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Uncharacterized protein	hydrolase activity catalytic activity	carbohydrate metabolic process organic substance metabolic process primary metabolic process metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR042301	Glycosyl hydrolase 115 superfamily	Homologous Superfamily
A, B	IPR041437	Gylcosyl hydrolase 115 C-terminal domain	Domain
A, B	IPR029018	Beta-hexosaminidase-like, domain 2	Homologous Superfamily
A, B	IPR024361	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal	Domain
A, B	IPR031924	Glycosyl hydrolase family 115	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.