Annotations: 3IYO

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Norovirus P2 domain-like	8093120	3002678	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Positive stranded ssRNA viruses-like	8093122	3000918	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Astrovirus capsid protein P1 domain-like	8093123	3002535	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Norovirus P2 domain-like	8093120	3002678	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Positive stranded ssRNA viruses-like	8093122	3000918	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Astrovirus capsid protein P1 domain-like	8093123	3002535	SCOP2B (2022-06-29)
C [auth D]	SCOP2 Family	Hepatitis virus capsid protein S-P1 domain-like	8093121	4007793	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Family	Hepatitis virus capsid protein P2 domain-like	8050973	4007137	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Superfamily	Astrovirus capsid protein P1 domain-like	8093123	3002535	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Superfamily	Norovirus P2 domain-like	8093120	3002678	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Superfamily	Positive stranded ssRNA viruses-like	8093122	3000918	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SP2_2nd	e3iyoA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Phage tail proteins	F: SP2_2nd	ECOD (1.6)
A	SP2_3rd	e3iyoA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Phage tail proteins	F: SP2_3rd	ECOD (1.6)
A	SP2_1st	e3iyoA1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: SP2_1st	ECOD (1.6)
B	SP2_2nd	e3iyoB2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Phage tail proteins	F: SP2_2nd	ECOD (1.6)
B	SP2_3rd	e3iyoB3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Phage tail proteins	F: SP2_3rd	ECOD (1.6)
B	SP2_1st	e3iyoB1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: SP2_1st	ECOD (1.6)
C [auth D]	SP2_2nd	e3iyoD2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Phage tail proteins	F: SP2_2nd	ECOD (1.6)
C [auth D]	SP2_3rd	e3iyoD3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Phage tail proteins	F: SP2_3rd	ECOD (1.6)
C [auth D]	SP2_1st	e3iyoD1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: SP2_1st	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth D]	PF20751	Structural protein 2 second domain (SP2_M)	Structural protein 2 second domain	This entry represents the second domain of structural protein 2 of the hepatitis E virus. This domain has a RIFT like fold. The high basic amino acid content of this protein has lead to the suggestion of a role in viral genomic RNA encapsidation.	Domain
A, B, C [auth D]	PF03014	Structural protein 2 nucleoplasmin-like domain (SP2)	Structural protein 2 nucleoplasmin-like domain	This family represents N-terminal domain of structural protein 2 of the hepatitis E virus. The high basic amino acid content of this protein has lead to the suggestion of a role in viral genomic RNA encapsidation.	Domain
A, B, C [auth D]	PF20752	Structural protein 2 C-terminal domain (SP2_C)	Structural protein 2 C-terminal domain	This entry represents the third domain of structural protein 2 of the hepatitis E virus. This domain has a RIFT-like fold. The high basic amino acid content of this protein has lead to the suggestion of a role in viral genomic RNA encapsidation.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth D]	Capsid protein	structural molecule activity RNA binding binding organic cyclic compound binding nucleic acid binding	-	viral capsid icosahedral viral capsid virion component T=1 icosahedral viral capsid extracellular region cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part viral capsid icosahedral viral capsid virion component T=1 icosahedral viral capsid extracellular region cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle host cell Golgi apparatus host cell surface

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth D]	IPR029053	Viral coat protein subunit	Homologous Superfamily
A, B, C [auth D]	IPR004261	Hepatitis E virus structural protein 2, N-terminal domain	Domain
A, B, C [auth D]	IPR048802	Structural protein 2, second domain	Domain
A, B, C [auth D]	IPR048794	Structural protein 2, C-terminal domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.