Annotations: 2FMT

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d2fmta1	All beta proteins	FMT C-terminal domain-like	FMT C-terminal domain-like	Post formyltransferase domain	Methionyl-tRNAfmet formyltransferase, C-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C [auth A]	d2fmta2	Alpha and beta proteins (a/b)	Formyltransferase	Formyltransferase	Formyltransferase	Methionyl-tRNAfmet formyltransferase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D [auth B]	d2fmtb1	All beta proteins	FMT C-terminal domain-like	FMT C-terminal domain-like	Post formyltransferase domain	Methionyl-tRNAfmet formyltransferase, C-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D [auth B]	d2fmtb2	Alpha and beta proteins (a/b)	Formyltransferase	Formyltransferase	Formyltransferase	Methionyl-tRNAfmet formyltransferase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	FMT C-terminal domain-like	8057639	3000015	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	Formyltransferase	8057638	3000030	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	FMT C-terminal domain-like	8057639	3000015	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	Formyltransferase	8057638	3000030	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	Formyl_trans_C	e2fmtA1	A: beta barrels	X: FMT C-terminal domain-like	H: FMT C-terminal domain-related (From Topology)	T: FMT C-terminal domain-related	F: Formyl_trans_C	ECOD (1.6)
C [auth A]	Formyl_trans_N	e2fmtA2	A: a/b three-layered sandwiches	X: Formyltransferase (From Topology)	H: Formyltransferase (From Topology)	T: Formyltransferase	F: Formyl_trans_N	ECOD (1.6)
D [auth B]	Formyl_trans_C	e2fmtB1	A: beta barrels	X: FMT C-terminal domain-like	H: FMT C-terminal domain-related (From Topology)	T: FMT C-terminal domain-related	F: Formyl_trans_C	ECOD (1.6)
D [auth B]	Formyl_trans_N	e2fmtB2	A: a/b three-layered sandwiches	X: Formyltransferase (From Topology)	H: Formyltransferase (From Topology)	T: Formyltransferase	F: Formyl_trans_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	3.40.50.170	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Formyl transferase, N-terminal domain	CATH (4.3.0)
C [auth A]	3.10.25.10	Alpha Beta	Roll	Methionyl-tRNA Fmet Formyltransferase	Chain A, domain 2	CATH (4.3.0)
D [auth B]	3.40.50.170	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Formyl transferase, N-terminal domain	CATH (4.3.0)
D [auth B]	3.10.25.10	Alpha Beta	Roll	Methionyl-tRNA Fmet Formyltransferase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth B]	PF02911	Formyl transferase, C-terminal domain (Formyl_trans_C)	Formyl transferase, C-terminal domain	-	Domain
C [auth A], D [auth B]	PF00551	Formyl transferase (Formyl_trans_N)	Formyl transferase	This family includes the following members. Glycinamide ribonucleotide transformylase catalyses the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyltetrahydrofolate deformylase produces ...	This family includes the following members. Glycinamide ribonucleotide transformylase catalyses the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyltetrahydrofolate deformylase produces formate from formyl- tetrahydrofolate. Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. Inclusion of the following members is supported by PSI-blast. HOXX_BRAJA (P31907) contains a related domain of unknown function. PRTH_PORGI (P46071) contains a related domain of unknown function. Y09P_MYCTU (Q50721) contains a related domain of unknown function.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D]	FORMYL-METHIONYL-TRNAFMET2	-	-	-
C [auth A], D [auth B]	METHIONYL-TRNA FMET FORMYLTRANSFERASE	catalytic activity, acting on RNA methionyl-tRNA formyltransferase activity transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA transferase activity hydroxymethyl-, formyl- and related transferase activity catalytic activity	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process charged-tRNA amino acid modification RNA processing cellular metabolic process tRNA modification primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process charged-tRNA amino acid modification RNA processing cellular metabolic process tRNA modification primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process conversion of methionyl-tRNA to N-formyl-methionyl-tRNA RNA modification biosynthetic process ncRNA metabolic process macromolecule modification nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth B]	IPR044135	Methionyl-tRNA formyltransferase, C-terminal domain	Domain
C [auth A], D [auth B]	IPR036477	Formyl transferase, N-terminal domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR037022	Formyl transferase, C-terminal domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR001555	Phosphoribosylglycinamide formyltransferase, active site	Active Site
C [auth A], D [auth B]	IPR005794	Methionyl-tRNA formyltransferase	Family
C [auth A], D [auth B]	IPR002376	Formyl transferase, N-terminal	Domain
C [auth A], D [auth B]	IPR005793	Formyl transferase, C-terminal	Domain
C [auth A], D [auth B]	IPR041711	Methionyl-tRNA formyltransferase, N-terminal domain	Domain
C [auth A], D [auth B]	IPR011034	Formyl transferase-like, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.