5VP1

Discovery of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders

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Version Number	Version Date	Version Type/Reason	Version Change	Revised CIF Category
1.0	2017-12-27	Initial release
1.1	2018-05-23		Data collection, Structure summary	audit_author
1.2	2024-03-13		Data collection, Database references, Derived calculations, Refinement description	chem_comp_atom, chem_comp_bond, database_2, pdbx_struct_conn_angle, struct_conn, struct_ncs_dom_lim	Download

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5VP1

Discovery of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders