4R5N

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

Changes made to a PDB entry after its initial release are considered to be either “major” or “minor”. The latest minor version of each major version is available as a file download. More information about the PDB versioning is available.

Version Number	Version Date	Version Type/Reason	Version Change	Revised CIF Category
1.0	2014-12-03	Initial release
1.1	2014-12-31		Database references
1.2	2023-09-20		Data collection, Database references, Derived calculations, Refinement description	chem_comp_atom, chem_comp_bond, database_2, pdbx_initial_refinement_model, pdbx_struct_conn_angle, struct_conn, struct_ref_seq_dif, struct_site	Download

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.