3EY4

Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model

Changes made to a PDB entry after its initial release are considered to be either “major” or “minor”. The latest minor version of each major version is available as a file download. More information about the PDB versioning is available.

Version Number	Version Date	Version Type/Reason	Version Change	Revised CIF Category
1.0	2008-11-11	Initial release
1.1	2011-07-13		Version format compliance
1.2	2017-10-25		Refinement description	software
1.3	2019-07-24		Data collection, Refinement description	software
1.4	2021-10-20		Database references, Derived calculations	database_2, struct_ref_seq_dif, struct_site
1.5	2023-12-27		Data collection	chem_comp_atom, chem_comp_bond	Download

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.