A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity
Harth, S., Kotzsch, A., Hu, J., Sebald, W., Mueller, T.D.(2010) PLoS One 5: e13049-e13049
- PubMed: 20927405 
- DOI: https://doi.org/10.1371/journal.pone.0013049
- Primary Citation of Related Structures:  
3NH7 - PubMed Abstract: 
Members of the TGF-β superfamily are characterized by a highly promiscuous ligand-receptor interaction as is readily apparent from the numeral discrepancy of only seven type I and five type II receptors available for more than 40 ligands. Structural and functional studies have been used to address the question of how specific signals can be deduced from a limited number of receptor combinations and to unravel the molecular mechanisms underlying the protein-protein recognition that allow such limited specificity.
Organizational Affiliation: 
Lehrstuhl für Physiologische Chemie II, Theodor-Boveri-Institut für Biowissenschaften der Universität Würzburg, Würzburg, Germany.