Mechanisms Underlying Dioxygen Reduction in Laccases. Structural and Modelling Studies Focusing on Proton Transfer.
Bento, I., Silva, C.S., Chen, Z., Martins, L.O., Lindley, P.F., Soares, C.M.(2010) BMC Struct Biol 10: 29
- PubMed: 20822511 
- DOI: https://doi.org/10.1186/1472-6807-10-28
- Primary Citation of Related Structures:  
2X87, 2X88 - PubMed Abstract: 
Laccases are enzymes that couple the oxidation of substrates with the reduction of dioxygen to water. They are the simplest members of the multi-copper oxidases and contain at least two types of copper centres; a mononuclear T1 and a trinuclear that includes two T3 and one T2 copper ions. Substrate oxidation takes place at the mononuclear centre whereas reduction of oxygen to water occurs at the trinuclear centre.
Organizational Affiliation: 
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal. bento@itqb.unl.pt