Exon 6 of human JAG1 encodes a conserved structural unit
Pintar, A., Guarnaccia, C., Dhir, S., Pongor, S.(2009) BMC Struct Biol 9: 43-43
- PubMed: 19586525 
- DOI: https://doi.org/10.1186/1472-6807-9-43
- Primary Citation of Related Structures:  
2KB9 - PubMed Abstract: 
Notch signaling drives developmental processes in all metazoans. The receptor binding region of the human Notch ligand Jagged-1 is made of a DSL (Delta/Serrate/Lag-2) domain and two atypical epidermal growth factor (EGF) repeats encoded by two exons, exon 5 and 6, which are out of phase with respect to the EGF domain boundaries.
Organizational Affiliation: 
International Centre for Genetic Engineering and Biotechnology, Protein Structure and Bioinformatics Group, AREA Science Park, Padriciano 99, Trieste, Italy. pintar@icgeb.org