Structure of the universal stress protein of Haemophilus influenzae.
Sousa, M.C., McKay, D.B.(2001) Structure 9: 1135-1141
- PubMed: 11738040 
- DOI: https://doi.org/10.1016/s0969-2126(01)00680-3
- Primary Citation of Related Structures:  
1JMV - PubMed Abstract: 
The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. However, neither the structure of UspA nor the biochemical mechanism by which it protects cells from the broad spectrum of stress agents is known.
Organizational Affiliation: 
Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.