Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices.
Ryu, S.E., Truneh, A., Sweet, R.W., Hendrickson, W.A.(1994) Structure 2: 59-74
- PubMed: 8075984 
- DOI: https://doi.org/10.1016/S0969-2126(00)00008-3
- Primary Citation of Related Structures:  
1CDH, 1CDI - PubMed Abstract: 
The T-cell surface glycoprotein CD4 interacts with class II molecules of the major histocompatibility complex (MHC) enhancing the signal for T-cell activation. Human CD4 also interacts, at high affinity, with the HIV envelope glycoprotein, gp120, to mediate T-cell infection by HIV. Crystal structures of amino-terminal two-domain (D1D2) fragments of human CD4, which contain the residues implicated in HIV and MHC interactions, have been reported earlier.
Organizational Affiliation: 
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.