Protein plasticity to the extreme: changing the topology of a 4-alpha-helical bundle with a single amino acid substitution.
Glykos, N.M., Cesareni, G., Kokkinidis, M.(1999) Structure 7: 597-603
- PubMed: 10404589 
- DOI: https://doi.org/10.1016/s0969-2126(99)80081-1
- Primary Citation of Related Structures:  
1B6Q - PubMed Abstract: 
Conventional wisdom has it that two proteins sharing 98.4% sequence identity have nearly identical three-dimensional structures. Here we provide a counter-example to this statement by showing that a single amino acid substitution can change the topology of a homodimeric 4-alpha-helical bundle protein.
Organizational Affiliation: 
Foundation for Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology, Heraklion, Crete, Greece.