Download MendeleyCrystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain
Phoo, W.W., El Sahili, A., ZHANG, Z.Z., CHEN, M.W., VASUDEVAN, S., LESCAR, J., LUO, D.To be published.
5YVU
Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain
- PDB DOI: https://doi.org/10.2210/pdb5YVU/pdb
- Classification: VIRAL PROTEIN
- Organism(s): dengue virus type 4, Bos taurus
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2017-11-27 Released: 2018-11-28
- Funding Organization(s): NTU, NMRC, NRF
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.49 Å
- R-Value Free: 0.266
- R-Value Work: 0.222
- R-Value Observed: 0.224
wwPDB Validation 3D Report Full Report
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Genome polyprotein | A [auth B] | 627 | dengue virus type 4 | Mutation(s): 1 |  |
UniProt | |||||
Find proteins for F8TEL4 (dengue virus type 4) Explore F8TEL4 Go to UniProtKB: F8TEL4 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | F8TEL4 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Genome polyprotein | B [auth A] | 55 | dengue virus type 4 | Mutation(s): 0 |  |
UniProt | |||||
Find proteins for F8TEL4 (dengue virus type 4) Explore F8TEL4 Go to UniProtKB: F8TEL4 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | F8TEL4 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Pancreatic trypsin inhibitor | C [auth I] | 55 | Bos taurus | Mutation(s): 0 |  |
UniProt | |||||
Find proteins for P00974 (Bos taurus) Explore P00974 Go to UniProtKB: P00974 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P00974 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GOL Query on GOL | D [auth B] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.49 Å
- R-Value Free: 0.266
- R-Value Work: 0.222
- R-Value Observed: 0.224
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 53.059 | α = 90 |
| b = 85.627 | β = 97.95 |
| c = 85.508 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| iMOSFLM | data reduction |
| Aimless | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2018-11-28 Deposition Author(s): Phoo, W.W., El Sahili, A.
| Funding Organization | Location | Grant Number |
|---|---|---|
| NTU | Singapore | STARTUP_GRANT |
| NMRC | Singapore | CBRG14051 |
| NMRC | Singapore | CBRG/0103/2016 |
| NRF | Singapore | NRF-CRP001-063 |
Revision History (Full details and data files)
- Version 1.0: 2018-11-28
Type: Initial release - Version 1.1: 2023-11-22
Changes: Data collection, Database references, Refinement description
