5YVU

Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth I]	d5yvui_	Small proteins	BPTI-like	BPTI-like	automated matches	automated matches	Bovine (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth I]	SCOP2B Superfamily	BPTI-like	8038485	3000628	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF00949	e5yvuB2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: PF00949	ECOD (1.6)
A [auth B]	PF20907	e5yvuB1	A: alpha arrays	X: C-terminal helical domain of RNA helicase (From Topology)	H: C-terminal helical domain of RNA helicase (From Topology)	T: C-terminal helical domain of RNA helicase	F: PF20907	ECOD (1.6)
A [auth B]	F_UNCLASSIFIED	e5yvuB4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
A [auth B]	PF07652	e5yvuB3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07652	ECOD (1.6)
C [auth I]	PF00014	e5yvuI1	A: few secondary structure elements	X: BPTI-like (From Topology)	H: BPTI-like (From Topology)	T: BPTI-like	F: PF00014	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth I]	4.10.410.10	Few Secondary Structures	Irregular	Factor Xa Inhibitor	Pancreatic trypsin inhibitor Kunitz domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF20907	Flavivirus NS3 helicase, C-terminal helical domain (Flav_NS3-hel_C)	Flavivirus NS3 helicase, C-terminal helical domain	This domain is found at the C-terminal end of NS3 helicase (Non- Non-structural protein 3-helicase, NS3-Hel) found in Flavivirus such as Zika virus (ZIKV) and Dengue virus type 1 (DENV-1). This protein binds RNA and unwinds dsRNA in the 3' to 5' dire ...	This domain is found at the C-terminal end of NS3 helicase (Non- Non-structural protein 3-helicase, NS3-Hel) found in Flavivirus such as Zika virus (ZIKV) and Dengue virus type 1 (DENV-1). This protein binds RNA and unwinds dsRNA in the 3' to 5' direction. It consists of three domains. This entry represent the final domain, which is mostly alpha-helical [1,2]. A highly conserved R residue located in this domain was proven essential for the enzymatic activities of the protein [3].	Domain
A [auth B]	PF07652	Flavivirus DEAD domain (Flavi_DEAD)	Flavivirus DEAD domain	-	Domain
B [auth A]	PF01002	Flavivirus non-structural protein NS2B (Flavi_NS2B)	Flavivirus non-structural protein NS2B	-	Family
C [auth I]	PF00014	Kunitz/Bovine pancreatic trypsin inhibitor domain (Kunitz_BPTI)	Kunitz/Bovine pancreatic trypsin inhibitor domain	Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the ...	Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP, Swiss:P17726). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways [1]. TAP molecules are highly dipolar [2], and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Genome polyprotein	RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity peptidase activity catalytic activity, acting on a protein serine hydrolase activity RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid helicase activity RNA helicase activity ATP-dependent activity, acting on RNA ATP-dependent activity protein binding protein dimerization activity cation binding metal ion binding RNA methyltransferase activity O-methyltransferase activity transferase activity, transferring one-carbon groups mRNA (nucleoside-2'-O-)-methyltransferase activity transferase activity S-adenosylmethionine-dependent methyltransferase activity methyltransferase activity mRNA methyltransferase activity 5'-3' RNA polymerase activity RNA polymerase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups mRNA 5'-cap (guanine-N7-)-methyltransferase activity N-methyltransferase activity structural molecule activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis cellular biosynthetic process cellular metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis cellular biosynthetic process cellular metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process viral genome replication biosynthetic process viral RNA genome replication organic cyclic compound biosynthetic process viral process organic substance biosynthetic process metabolic process macromolecule metabolic process symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms response to stimulus response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated perturbation of host defense response response to host defenses symbiont-mediated suppression of host JAK-STAT cascade response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism symbiont-mediated perturbation of host defenses response to external stimulus biological process involved in interaction with host symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity modulation by symbiont of host process catabolic process regulation of cellular process autophagy positive regulation of biological process modulation by virus of host process positive regulation of cellular metabolic process regulation of autophagy cellular catabolic process positive regulation of metabolic process induction by virus of host autophagy process utilizing autophagic mechanism positive regulation of cellular process modulation by virus of host cellular process positive regulation of autophagy regulation of biological process modulation by virus of host autophagy biological regulation regulation of cellular metabolic process regulation of catabolic process symbiont-mediated perturbation of host autophagy positive regulation of catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process regulation of metabolic process symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host organonitrogen compound metabolic process proteolysis protein metabolic process	membrane cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region host cell mitochondrion host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum host cell membrane host cell endomembrane system membrane cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region host cell mitochondrion host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum host cell membrane host cell endomembrane system host cell endoplasmic reticulum membrane viral capsid virion component virion membrane extracellular region viral membrane viral envelope
B [auth A]	Genome polyprotein	RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity peptidase activity catalytic activity, acting on a protein serine hydrolase activity RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid helicase activity RNA helicase activity ATP-dependent activity, acting on RNA ATP-dependent activity protein binding protein dimerization activity cation binding metal ion binding RNA methyltransferase activity O-methyltransferase activity transferase activity, transferring one-carbon groups mRNA (nucleoside-2'-O-)-methyltransferase activity transferase activity S-adenosylmethionine-dependent methyltransferase activity methyltransferase activity mRNA methyltransferase activity 5'-3' RNA polymerase activity RNA polymerase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups mRNA 5'-cap (guanine-N7-)-methyltransferase activity N-methyltransferase activity structural molecule activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis cellular biosynthetic process cellular metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis cellular biosynthetic process cellular metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process viral genome replication biosynthetic process viral RNA genome replication organic cyclic compound biosynthetic process viral process organic substance biosynthetic process metabolic process macromolecule metabolic process symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms response to stimulus response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated perturbation of host defense response response to host defenses symbiont-mediated suppression of host JAK-STAT cascade response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism symbiont-mediated perturbation of host defenses response to external stimulus biological process involved in interaction with host symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity modulation by symbiont of host process catabolic process regulation of cellular process autophagy positive regulation of biological process modulation by virus of host process positive regulation of cellular metabolic process regulation of autophagy cellular catabolic process positive regulation of metabolic process induction by virus of host autophagy process utilizing autophagic mechanism positive regulation of cellular process modulation by virus of host cellular process positive regulation of autophagy regulation of biological process modulation by virus of host autophagy biological regulation regulation of cellular metabolic process regulation of catabolic process symbiont-mediated perturbation of host autophagy positive regulation of catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process regulation of metabolic process symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host organonitrogen compound metabolic process proteolysis protein metabolic process	membrane cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region host cell mitochondrion host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum host cell membrane host cell endomembrane system membrane cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region host cell mitochondrion host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum host cell membrane host cell endomembrane system host cell endoplasmic reticulum membrane viral capsid virion component virion membrane extracellular region viral membrane viral envelope
C [auth I]	Pancreatic trypsin inhibitor	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity protein binding enzyme binding zymogen binding protease binding sulfate binding anion binding sulfur compound binding potassium channel regulator activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity potassium channel inhibitor activity transporter regulator activity channel inhibitor activity	negative regulation of hydrolase activity negative regulation of proteolysis regulation of serine-type endopeptidase activity regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of peptidase activity organic substance metabolic process regulation of proteolysis regulation of serine-type peptidase activity proteolysis regulation of endopeptidase activity negative regulation of hydrolase activity negative regulation of proteolysis regulation of serine-type endopeptidase activity regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of peptidase activity organic substance metabolic process regulation of proteolysis regulation of serine-type peptidase activity proteolysis regulation of endopeptidase activity protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of serine-type endopeptidase activity regulation of biological process organonitrogen compound metabolic process negative regulation of serine-type peptidase activity regulation of protein metabolic process negative regulation of metabolic process regulation of peptidase activity biological regulation negative regulation of molecular function primary metabolic process regulation of macromolecule metabolic process regulation of molecular function regulation of hydrolase activity metabolic process macromolecule metabolic process regulation of metabolic process multicellular organismal process regulation of body fluid levels regulation of cellular process response to stimulus regulation of cell activation negative regulation of cell adhesion negative regulation of platelet activation regulation of coagulation regulation of biological quality response to wounding negative regulation of homotypic cell-cell adhesion negative regulation of wound healing negative regulation of blood coagulation response to external stimulus blood coagulation negative regulation of hemostasis regulation of platelet activation regulation of response to stimulus negative regulation of response to external stimulus negative regulation of cell-cell adhesion regulation of wound healing negative regulation of multicellular organismal process platelet activation regulation of response to external stimulus homotypic cell-cell adhesion regulation of response to wounding cell adhesion cell-cell adhesion response to stress regulation of response to stress negative regulation of cellular process coagulation regulation of cell-cell adhesion regulation of multicellular organismal process regulation of hemostasis wound healing negative regulation of response to stimulus regulation of homotypic cell-cell adhesion regulation of cell adhesion regulation of blood coagulation hemostasis cell activation negative regulation of platelet aggregation negative regulation of response to wounding platelet aggregation negative regulation of cell activation regulation of platelet aggregation negative regulation of coagulation cellular process cellular response to stimulus negative regulation of thrombin-activated receptor signaling pathway signaling negative regulation of signaling regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication cell communication thrombin-activated receptor signaling pathway signal transduction regulation of G protein-coupled receptor signaling pathway regulation of signaling regulation of thrombin-activated receptor signaling pathway negative regulation of signal transduction regulation of cell communication G protein-coupled receptor signaling pathway zymogen activation cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process organic substance biosynthetic process protein processing trypsinogen activation	protein-containing complex serine protease inhibitor complex protease inhibitor complex peptidase inhibitor complex extracellular region extracellular space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR000208	RNA-directed RNA polymerase, fingers/palm subdomains, flavivirus	Domain
A [auth B]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A [auth B]	IPR001122	Capsid protein C, flavivirus	Domain
A [auth B]	IPR027287	Glycoprotein E, immunoglobulin-like domain, flavivirus	Domain
A [auth B]	IPR014412	Genome polyprotein, Flavivirus	Family
A [auth B]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
A [auth B]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth B]	IPR026490	mRNA cap 0/1 methyltransferase	Domain
A [auth B]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A [auth B]	IPR001650	Helicase, C-terminal domain-like	Domain
A [auth B]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A [auth B]	IPR013755	Flaviviral glycoprotein E, central domain, subdomain 1	Homologous Superfamily
A [auth B]	IPR000752	Flavivirus non-structural protein NS2A	Domain
A [auth B]	IPR047530	RNA-dependent RNA polymerase, flavivirus	Domain
A [auth B]	IPR049486	Flavivridae NS3 helicase, C-terminal helical domain	Domain
A [auth B]	IPR046811	RNA-directed RNA polymerase, thumb subdomain, flavivirus	Domain
A [auth B]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
A [auth B]	IPR002877	Ribosomal RNA methyltransferase, FtsJ domain	Domain
A [auth B]	IPR038302	Envelope glycoprotein M superfamily, flavivirus	Homologous Superfamily
A [auth B]	IPR000069	Envelope glycoprotein M, flavivirus	Domain
A [auth B]	IPR011492	Non-structural protein NS3-like, DEAD box helicase, flavivirus	Domain
A [auth B]	IPR038345	Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily	Homologous Superfamily
A [auth B]	IPR038688	Flavivirus polyprotein propeptide superfamily	Homologous Superfamily
A [auth B]	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A [auth B]	IPR026470	Flavivirus envelope glycoprotein E, Stem/Anchor domain	Domain
A [auth B]	IPR011998	Envelope glycoprotein E, central and dimerisation domain, flavivirus	Domain
A [auth B]	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
A [auth B]	IPR037172	Flavivirus capsid protein C superfamily	Homologous Superfamily
A [auth B]	IPR000404	Flavivirus non-structural protein NS4A	Domain
A [auth B]	IPR000487	Non-structural protein NS2B, flavivirus	Domain
A [auth B]	IPR001528	Flavivirus non-structural protein NS4B	Domain
A [auth B]	IPR001157	Non-structural protein NS1, flavivirus	Domain
A [auth B]	IPR013756	Flaviviral glycoprotein E, central domain, subdomain 2	Homologous Superfamily
A [auth B]	IPR001850	Non-structural protein NS3, peptidase S7, flavivirus	Domain
A [auth B]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth B]	IPR002535	Flavivirus polyprotein propeptide	Domain
A [auth B]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A [auth B]	IPR007094	RNA-directed RNA polymerase, catalytic domain	Domain
B [auth A]	IPR000208	RNA-directed RNA polymerase, fingers/palm subdomains, flavivirus	Domain
B [auth A]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
B [auth A]	IPR001122	Capsid protein C, flavivirus	Domain
B [auth A]	IPR027287	Glycoprotein E, immunoglobulin-like domain, flavivirus	Domain
B [auth A]	IPR014412	Genome polyprotein, Flavivirus	Family
B [auth A]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
B [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth A]	IPR026490	mRNA cap 0/1 methyltransferase	Domain
B [auth A]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B [auth A]	IPR001650	Helicase, C-terminal domain-like	Domain
B [auth A]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
B [auth A]	IPR013755	Flaviviral glycoprotein E, central domain, subdomain 1	Homologous Superfamily
B [auth A]	IPR000752	Flavivirus non-structural protein NS2A	Domain
B [auth A]	IPR047530	RNA-dependent RNA polymerase, flavivirus	Domain
B [auth A]	IPR049486	Flavivridae NS3 helicase, C-terminal helical domain	Domain
B [auth A]	IPR046811	RNA-directed RNA polymerase, thumb subdomain, flavivirus	Domain
B [auth A]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
B [auth A]	IPR002877	Ribosomal RNA methyltransferase, FtsJ domain	Domain
B [auth A]	IPR038302	Envelope glycoprotein M superfamily, flavivirus	Homologous Superfamily
B [auth A]	IPR000069	Envelope glycoprotein M, flavivirus	Domain
B [auth A]	IPR011492	Non-structural protein NS3-like, DEAD box helicase, flavivirus	Domain
B [auth A]	IPR038345	Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily	Homologous Superfamily
B [auth A]	IPR038688	Flavivirus polyprotein propeptide superfamily	Homologous Superfamily
B [auth A]	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
B [auth A]	IPR026470	Flavivirus envelope glycoprotein E, Stem/Anchor domain	Domain
B [auth A]	IPR011998	Envelope glycoprotein E, central and dimerisation domain, flavivirus	Domain
B [auth A]	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
B [auth A]	IPR037172	Flavivirus capsid protein C superfamily	Homologous Superfamily
B [auth A]	IPR000404	Flavivirus non-structural protein NS4A	Domain
B [auth A]	IPR000487	Non-structural protein NS2B, flavivirus	Domain
B [auth A]	IPR001528	Flavivirus non-structural protein NS4B	Domain
B [auth A]	IPR001157	Non-structural protein NS1, flavivirus	Domain
B [auth A]	IPR013756	Flaviviral glycoprotein E, central domain, subdomain 2	Homologous Superfamily
B [auth A]	IPR001850	Non-structural protein NS3, peptidase S7, flavivirus	Domain
B [auth A]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
B [auth A]	IPR002535	Flavivirus polyprotein propeptide	Domain
B [auth A]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B [auth A]	IPR007094	RNA-directed RNA polymerase, catalytic domain	Domain
C [auth I]	IPR020901	Proteinase inhibitor I2, Kunitz, conserved site	Conserved Site
C [auth I]	IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily	Homologous Superfamily
C [auth I]	IPR002223	Pancreatic trypsin inhibitor Kunitz domain	Domain