5HOB

p73 homo-tetramerization domain mutant I

PDB DOI: https://doi.org/10.2210/pdb5HOB/pdb

Classification: TRANSCRIPTION
Organism(s): Homo sapiens
Expression System: Escherichia coli
Mutation(s): Yes

Deposited: 2016-01-19 Released: 2016-10-19
Deposition Author(s): Coutandin, D., Krojer, T., Salah, E., Mathea, S., Knapp, S., Dotsch, V.

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 1.22 Å
R-Value Free: 0.214
R-Value Work: 0.188
R-Value Observed: 0.190

wwPDB Validation 3D Report Full Report

This is version 1.1 of the entry. See complete history.

Literature

Structural basis of p63/p73 hetero-tetramerization

Gebel, J., Luh, L., Coutandin, D., Lohr, F., Schafer, B., Sumyk, M., Buchner, L., Krojer, T., Salah, E., Mathea, S., Guntert, P., Knapp, S., Dotsch, V.

To be published.

Macromolecule Content

Total Structure Weight: 48.3 kDa
Atom Count: 3,296
Modelled Residue Count: 365
Deposited Residue Count: 400
Unique protein chains: 1

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Tumor protein p73	A, B, C, D, E A, B, C, D, E, F, G, H	50	Homo sapiens	Mutation(s): 4 Gene Names: TP73, P73
UniProt & NIH Common Fund Data Resources
Find proteins for O15350 (Homo sapiens) Explore O15350 Go to UniProtKB: O15350
PHAROS: O15350 GTEx: ENSG00000078900
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	O15350
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 1 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
MG Query on MG Download Ideal Coordinates CCD File SDF format, chain I [auth F] MOL2 format, chain I [auth F]	I [auth F]	MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N		Interactions Focus chain I [auth F] Interactions & Density Focus chain I [auth F]

Experimental Data & Validation

Experimental Data

Method: X-RAY DIFFRACTION
Resolution: 1.22 Å
R-Value Free: 0.214
R-Value Work: 0.188
R-Value Observed: 0.190
Space Group: P 1

Unit Cell:

Length ( Å )	Angle ( ˚ )
a = 29.05	α = 89.6
b = 48.4	β = 83.2
c = 75.73	γ = 74.27

Software Package:

Software Name	Purpose
XSCALE	data scaling
PHASER	phasing
PHENIX	refinement
PDB_EXTRACT	data extraction
XDS	data reduction

Structure Validation

View Full Validation Report

Entry History

Deposition Data

Released Date: 2016-10-19

Deposition Author(s):

Revision History (Full details and data files)

Version 1.0: 2016-10-19
Type: Initial release
Version 1.1: 2024-01-10
Changes: Data collection, Database references, Refinement description

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.