5HOB

p73 homo-tetramerization domain mutant I

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d5hobd_	All alpha proteins	p53 tetramerization domain	p53 tetramerization domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d5hobf_	All alpha proteins	p53 tetramerization domain	p53 tetramerization domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5hoba_	All alpha proteins	p53 tetramerization domain	p53 tetramerization domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5hobb_	All alpha proteins	p53 tetramerization domain	p53 tetramerization domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5hobc_	All alpha proteins	p53 tetramerization domain	p53 tetramerization domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d5hobe1	All alpha proteins	p53 tetramerization domain	p53 tetramerization domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d5hobe2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d5hobg_	All alpha proteins	p53 tetramerization domain	p53 tetramerization domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d5hobh1	All alpha proteins	p53 tetramerization domain	p53 tetramerization domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d5hobh2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	p53 tetramerization domain	8072269	3000414	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	p53 tetramerization domain	8072269	3000414	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	p53 tetramerization domain	8072269	3000414	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	p53 tetramerization domain	8072269	3000414	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	p53 tetramerization domain	8072269	3000414	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	p53 tetramerization domain	8072269	3000414	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	p53 tetramerization domain	8072269	3000414	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	p53 tetramerization domain	8072269	3000414	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	PF07710	e5hobD1	A: alpha duplicates or obligate multimers	X: p53 tetramerization domain (From Topology)	H: p53 tetramerization domain (From Topology)	T: p53 tetramerization domain	F: PF07710	ECOD (1.6)
F	PF07710	e5hobF1	A: alpha duplicates or obligate multimers	X: p53 tetramerization domain (From Topology)	H: p53 tetramerization domain (From Topology)	T: p53 tetramerization domain	F: PF07710	ECOD (1.6)
A	PF07710	e5hobA1	A: alpha duplicates or obligate multimers	X: p53 tetramerization domain (From Topology)	H: p53 tetramerization domain (From Topology)	T: p53 tetramerization domain	F: PF07710	ECOD (1.6)
B	PF07710	e5hobB1	A: alpha duplicates or obligate multimers	X: p53 tetramerization domain (From Topology)	H: p53 tetramerization domain (From Topology)	T: p53 tetramerization domain	F: PF07710	ECOD (1.6)
C	PF07710	e5hobC1	A: alpha duplicates or obligate multimers	X: p53 tetramerization domain (From Topology)	H: p53 tetramerization domain (From Topology)	T: p53 tetramerization domain	F: PF07710	ECOD (1.6)
E	PF07710	e5hobE1	A: alpha duplicates or obligate multimers	X: p53 tetramerization domain (From Topology)	H: p53 tetramerization domain (From Topology)	T: p53 tetramerization domain	F: PF07710	ECOD (1.6)
G	PF07710	e5hobG1	A: alpha duplicates or obligate multimers	X: p53 tetramerization domain (From Topology)	H: p53 tetramerization domain (From Topology)	T: p53 tetramerization domain	F: PF07710	ECOD (1.6)
H	PF07710	e5hobH1	A: alpha duplicates or obligate multimers	X: p53 tetramerization domain (From Topology)	H: p53 tetramerization domain (From Topology)	T: p53 tetramerization domain	F: PF07710	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
F	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
A	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
B	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
C	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
E	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
G	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
H	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF07710	P53 tetramerisation motif (P53_tetramer)	P53 tetramerisation motif	-	Motif

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Tumor protein p73	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding p53 binding transcription factor binding transcription coregulator binding transcription corepressor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding MDM2/MDM4 family protein binding kinase binding enzyme binding protein kinase binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons negative regulation of neuron differentiation regulation of neuron differentiation response to chemical response to xenobiotic stimulus cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein tetramerization protein-containing complex assembly cellular component organization or biogenesis mismatch repair primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process macromolecule metabolic process DNA repair regulation of biosynthetic process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process regulation of growth regulation of cardiac muscle tissue growth developmental growth cardiac muscle cell proliferation negative regulation of cardiac muscle tissue growth organ growth striated muscle tissue development negative regulation of organ growth negative regulation of growth regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation regulation of multicellular organismal process cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation heart development negative regulation of cell population proliferation heart growth regulation of multicellular organismal development cell population proliferation regulation of developmental growth negative regulation of heart growth cardiac muscle tissue development animal organ development growth tissue development circulatory system development negative regulation of developmental growth regulation of cell population proliferation negative regulation of multicellular organismal process negative regulation of cardiac muscle cell proliferation respiratory tube development positive regulation of lung ciliated cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation positive regulation of developmental process positive regulation of cell differentiation lung development respiratory system development epithelium development lung ciliated cell differentiation tube development regulation of lung ciliated cell differentiation lung epithelium development positive regulation of epithelial cell differentiation lung epithelial cell differentiation lung cell differentiation positive regulation of multicellular organismal process kidney development renal system development positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of mitotic cell cycle cell cycle regulation of cell cycle mitotic cell cycle response to organic substance response to organonitrogen compound response to nitrogen compound positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication positive regulation of signaling apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway signal transduction by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of nervous system development cell development regulation of neurogenesis regulation of gliogenesis positive regulation of gliogenesis regulation of cell development regulation of nervous system development gliogenesis positive regulation of neurogenesis positive regulation of oligodendrocyte differentiation regulation of glial cell differentiation positive regulation of cell development positive regulation of glial cell differentiation central nervous system development oligodendrocyte differentiation glial cell differentiation regulation of oligodendrocyte differentiation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle Golgi apparatus intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system cell junction nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036674	p53-like tetramerisation domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011615	p53, DNA-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001660	Sterile alpha motif domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR002117	p53 tumour suppressor family	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR037612	Tumour protein p73, SAM domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR010991	p53, tetramerisation domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: O15350	adult T-cell leukemia/lymphoma Inflammation small cell lung carcinoma breast carcinoma alveolar rhabdomyosarcoma acute T cell leukemia breast cancer primary ciliary dyskinesia lissencephaly spectrum disorders malignant ependymoma small cell carcinoma cancer lung benign neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.