2AVT

Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium.

(2006) BMC Struct Biol 6: 2-2

• PubMed: 16403212 Search on PubMedSearch on PubMed Central
• DOI: https://doi.org/10.1186/1472-6807-6-2
• Primary Citation of Related Structures:  
  2AVT


• PubMed Abstract: 
  

  Sliding DNA clamps are processivity factors that are required for efficient DNA replication. DNA polymerases maintain proximity to nucleic acid templates by interacting with sliding clamps that encircle DNA and thereby link the polymerase enzyme to the DNA substrate. Although the structures of sliding clamps from Gram-negative bacteria (E. coli), eukaryotes, archaea, and T4-like bacteriophages are well-known, the structure of a sliding clamp from Gram-positive bacteria has not been reported previously.

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Organizational Affiliation: 

Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA. maria.argiriadi@abbott.com