Download MendeleyAdam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.
Janes, P.W., Saha, N., Barton, W.A., Kolev, M.V., Wimmer-Kleikamp, S.H., Nievergall, E., Blobel, C.P., Himanen, J.-P., Lackmann, M., Nikolov, D.B.(2005) Cell 123: 291-304
- PubMed: 16239135
- DOI: https://doi.org/10.1016/j.cell.2005.10.004
- Primary Citation of Related Structures:
2AO7 - PubMed Abstract:
Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.
Organizational Affiliation:
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
