Annotations: 2AO7

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21299	e2ao7A2	A: few secondary structure elements	X: Disulfide-rich domain in A Disintegrin And Metalloprotease (ADAM) domain-containing proteins (From Topology)	H: Disulfide-rich domain in A Disintegrin And Metalloprotease (ADAM) domain-containing proteins (From Topology)	T: Disulfide-rich domain in A Disintegrin And Metalloprotease (ADAM) domain-containing proteins	F: PF21299	ECOD (1.6)
A	PF00200	e2ao7A4	A: few secondary structure elements	X: Blood coagulation inhibitor (disintegrin) (From Topology)	H: Blood coagulation inhibitor (disintegrin) (From Topology)	T: Blood coagulation inhibitor (disintegrin)	F: PF00200	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21299	ADAM10, cysteine-rich domain (ADAM10_Cys-rich)	ADAM10, cysteine-rich domain	Disintegrin and metalloproteinase domain-containing protein 10 (ADA10) is a transmembrane endopeptidase responsible for the proteolytic release of several cell-surface proteins, including the membrane-bound precursor of TNF-alpha, ligands and recepto ...	Disintegrin and metalloproteinase domain-containing protein 10 (ADA10) is a transmembrane endopeptidase responsible for the proteolytic release of several cell-surface proteins, including the membrane-bound precursor of TNF-alpha, ligands and receptors of the Notch, Eph, and erbB families, thereby activating signaling pathways critical for tumour initiation and maintenance. This entry represents the cysteine-rich domain which mediates non-catalytic interactions with the substrate that are key for effective cleavage [1-3]. This domain, together with disintegrin domain (Pfam:PF00200), plays an important modulatory role.	Domain
A	PF00200	Disintegrin (Disintegrin)	Disintegrin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ADAM 10	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity SH3 domain binding protein binding binding protein domain specific binding endopeptidase activity cation binding ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity SH3 domain binding protein binding binding protein domain specific binding endopeptidase activity cation binding ion binding metal ion binding small molecule binding metallodipeptidase activity exopeptidase activity dipeptidase activity metalloexopeptidase activity metalloendopeptidase activity identical protein binding protein homodimerization activity protein dimerization activity kinase binding enzyme binding protein kinase binding metalloendopeptidase activity involved in amyloid precursor protein catabolic process	developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization organic substance metabolic process developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization organic substance metabolic process organonitrogen compound metabolic process proteolysis membrane protein proteolysis constitutive protein ectodomain proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process membrane protein ectodomain proteolysis cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly pore complex assembly postsynapse organization synapse organization multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development protein phosphorylation phosphorylation cellular metabolic process macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process amyloid precursor protein catabolic process amyloid precursor protein metabolic process organonitrogen compound catabolic process protein catabolic process at postsynapse catabolic process protein catabolic process protein catabolic process at synapse macromolecule catabolic process organic substance catabolic process cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell communication Notch signaling pathway signal transduction regulation of cellular component organization regulation of postsynapse organization regulation of synapse organization regulation of synapse structure or activity regulation of biological quality cell adhesion regulation of cell adhesion negative regulation of cellular process negative regulation of biological process negative regulation of cell adhesion regulation of growth positive regulation of biological process growth positive regulation of cell growth regulation of cell growth cell growth positive regulation of growth positive regulation of cellular process regulation of signaling regulation of signal transduction regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication cellular biosynthetic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process organic substance biosynthetic process protein processing cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation protein localization regulation of localization cellular localization protein localization to synapse regulation of protein localization regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane localization cellular macromolecule localization regulation of protein localization to membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to cell periphery protein localization to postsynaptic membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels regulation of cellular localization macromolecule localization protein localization to organelle protein localization to postsynapse protein localization to cell junction receptor localization to synapse monocyte activation immune system process cell activation myeloid leukocyte activation leukocyte activation positive regulation of locomotion regulation of cell motility positive regulation of T cell chemotaxis positive regulation of chemotaxis positive regulation of cell migration regulation of lymphocyte chemotaxis taxis cell migration regulation of immune system process regulation of mononuclear cell migration positive regulation of immune system process chemotaxis regulation of leukocyte chemotaxis positive regulation of lymphocyte migration regulation of leukocyte migration lymphocyte migration response to external stimulus positive regulation of leukocyte chemotaxis leukocyte migration regulation of locomotion response to chemical regulation of T cell migration regulation of T cell chemotaxis regulation of response to external stimulus lymphocyte chemotaxis regulation of lymphocyte migration positive regulation of lymphocyte chemotaxis positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of cell motility regulation of cell migration positive regulation of mononuclear cell migration T cell chemotaxis cell motility locomotion cell chemotaxis positive regulation of T cell migration positive regulation of leukocyte migration regulation of chemotaxis cellular response to chemical stimulus mononuclear cell migration T cell migration leukocyte chemotaxis regulation of multicellular organismal development regulation of developmental process regulation of vasculature development vasculature development circulatory system development regulation of multicellular organismal process system development peptide hormone processing signaling receptor ligand precursor processing epidermal growth factor receptor ligand maturation amide metabolic process regulation of hormone levels hormone metabolic process negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process response to organic substance response to cytokine response to tumor necrosis factor	somatodendritic compartment cell projection dendrite dendritic tree neuron projection cellular anatomical entity plasma membrane bounded cell projection intracellular anatomical structure cytoplasm synapse cell junction glutamatergic synapse membrane-bounded organelle intracellular membrane-bounded organelle somatodendritic compartment cell projection dendrite dendritic tree neuron projection cellular anatomical entity plasma membrane bounded cell projection intracellular anatomical structure cytoplasm synapse cell junction glutamatergic synapse membrane-bounded organelle intracellular membrane-bounded organelle endomembrane system intracellular organelle perinuclear endoplasmic reticulum perinuclear region of cytoplasm organelle endoplasmic reticulum cell-cell junction adherens junction anchoring junction Golgi apparatus Golgi membrane membrane bounding membrane of organelle organelle membrane axon protein-containing complex pore complex membrane protein complex cell periphery plasma membrane plasma membrane region synaptic membrane intracellular vesicle cytoplasmic vesicle clathrin-coated vesicle coated vesicle vesicle Golgi-associated vesicle cell surface postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse tetraspanin-enriched microdomain nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001590	Peptidase M12B, ADAM/reprolysin	Domain
A	IPR034025	ADAM10/ADAM17 catalytic domain	Domain
A	IPR001762	Disintegrin domain	Domain
A	IPR036436	Disintegrin domain superfamily	Homologous Superfamily
A	IPR024079	Metallopeptidase, catalytic domain superfamily	Homologous Superfamily
A	IPR049038	ADAM10, cysteine-rich domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Bitopic proteins	Peptidase MA	Mammalian disintegrin-metalloprotease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.