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Structure of the E. coli ribosomal termination complex with release factor 2
 
 
DOI:10.2210/pdb1ml5/pdb
1ML5
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Ribosome
    Structure Weight: 2153315.72
     
    Molecule:30S 16S RIBOSOMAL RNA
    Polymer:1Type:polyribonucleotideLength:1522
    Chains:A
    Molecule:T-RNA(PHE)
    Polymer:2Type:polyribonucleotideLength:76
    Chains:B
    Other Details:tRNA P-SITE
    Molecule:A- AND P-SITE MESSENGER RNA CODONS
    Polymer:3Type:polyribonucleotideLength:6
    Chains:C
    Other Details:6 NT LONG MRNA FRAGMENT
    Molecule:50S 23S RIBOSOMAL RNA
    Polymer:4Type:polyribonucleotideLength:2916
    Chains:a
    Molecule:50S 5S RIBOSOMAL RNA
    Polymer:5Type:polyribonucleotideLength:123
    Chains:b
    Molecule:Peptide chain release factor 2
    Polymer:6Type:polypeptide(L)Length:365
    Chains:Z
    Other Details:EM reconstruction of the backbone trace of the ribosome
    Molecule:30S RIBOSOMAL PROTEIN S2
    Polymer:7Type:polypeptide(L)Length:256
    Chains:E
    Molecule:30S RIBOSOMAL PROTEIN S3
    Polymer:8Type:polypeptide(L)Length:239
    Chains:F
    Molecule:30S RIBOSOMAL PROTEIN S4
    Polymer:9Type:polypeptide(L)Length:209
    Chains:G
    Molecule:30S RIBOSOMAL PROTEIN S5
    Polymer:10Type:polypeptide(L)Length:162
    Chains:H
    Molecule:30S RIBOSOMAL PROTEIN S6
    Polymer:11Type:polypeptide(L)Length:101
    Chains:I
    Molecule:30S RIBOSOMAL PROTEIN S7
    Polymer:12Type:polypeptide(L)Length:156
    Chains:J
    Molecule:30S RIBOSOMAL PROTEIN S8
    Polymer:13Type:polypeptide(L)Length:138
    Chains:K
    Molecule:30S RIBOSOMAL PROTEIN S9
    Polymer:14Type:polypeptide(L)Length:128
    Chains:L
    Molecule:30S RIBOSOMAL PROTEIN S10
    Polymer:15Type:polypeptide(L)Length:105
    Chains:M
    Molecule:30S RIBOSOMAL PROTEIN S11
    Polymer:16Type:polypeptide(L)Length:129
    Chains:N
    Molecule:30S RIBOSOMAL PROTEIN S12
    Polymer:17Type:polypeptide(L)Length:135
    Chains:O
    Molecule:30S RIBOSOMAL PROTEIN S13
    Polymer:18Type:polypeptide(L)Length:126
    Chains:P
    Molecule:30S RIBOSOMAL PROTEIN S14
    Polymer:19Type:polypeptide(L)Length:61
    Chains:Q
    Molecule:30S RIBOSOMAL PROTEIN S15
    Polymer:20Type:polypeptide(L)Length:89
    Chains:R
    Molecule:30S RIBOSOMAL PROTEIN S16
    Polymer:21Type:polypeptide(L)Length:91
    Chains:S
    Molecule:30S RIBOSOMAL PROTEIN S17
    Polymer:22Type:polypeptide(L)Length:105
    Chains:T
    Molecule:30S RIBOSOMAL PROTEIN S18
    Polymer:23Type:polypeptide(L)Length:88
    Chains:U
    Molecule:30S RIBOSOMAL PROTEIN S19
    Polymer:24Type:polypeptide(L)Length:93
    Chains:V
    Molecule:30S RIBOSOMAL PROTEIN S20
    Polymer:25Type:polypeptide(L)Length:106
    Chains:W
    Molecule:30S RIBOSOMAL PROTEIN THX
    Polymer:26Type:polypeptide(L)Length:26
    Chains:X
    Molecule:50S RIBOSOMAL PROTEIN L1
    Polymer:27Type:polypeptide(L)Length:228
    Chains:c
    Molecule:50S RIBOSOMAL PROTEIN L2
    Polymer:28Type:polypeptide(L)Length:178
    Chains:d
    Molecule:50S RIBOSOMAL PROTEIN L3
    Polymer:29Type:polypeptide(L)Length:338
    Chains:e
    Molecule:50S RIBOSOMAL PROTEIN L4
    Polymer:30Type:polypeptide(L)Length:246
    Chains:f
    Molecule:50S RIBOSOMAL PROTEIN L5
    Polymer:31Type:polypeptide(L)Length:176
    Chains:g
    Molecule:50S RIBOSOMAL PROTEIN L6
    Polymer:32Type:polypeptide(L)Length:177
    Chains:h
    Molecule:50S RIBOSOMAL PROTEIN L11
    Polymer:33Type:polypeptide(L)Length:141
    Chains:l
    Molecule:50S RIBOSOMAL PROTEIN L13
    Polymer:34Type:polypeptide(L)Length:145
    Chains:m
    Molecule:50S RIBOSOMAL PROTEIN L14
    Polymer:35Type:polypeptide(L)Length:122
    Chains:n
    Molecule:50S RIBOSOMAL PROTEIN L15
    Polymer:36Type:polypeptide(L)Length:164
    Chains:o
    Molecule:50S RIBOSOMAL PROTEIN L16
    Polymer:37Type:polypeptide(L)Length:138
    Chains:p
    Molecule:50S RIBOSOMAL PROTEIN L18
    Polymer:38Type:polypeptide(L)Length:186
    Chains:q
    Molecule:50S RIBOSOMAL PROTEIN L19
    Polymer:39Type:polypeptide(L)Length:66
    Chains:r
    Molecule:50S RIBOSOMAL PROTEIN L22
    Polymer:40Type:polypeptide(L)Length:113
    Chains:s
    Molecule:50S RIBOSOMAL PROTEIN L23
    Polymer:41Type:polypeptide(L)Length:84
    Chains:t
    Molecule:50S RIBOSOMAL PROTEIN L24
    Polymer:42Type:polypeptide(L)Length:119
    Chains:u
    Molecule:50S RIBOSOMAL PROTEIN L25
    Polymer:43Type:polypeptide(L)Length:94
    Chains:v
    Molecule:50S RIBOSOMAL PROTEIN L29
    Polymer:44Type:polypeptide(L)Length:70
    Chains:w
    Molecule:50S RIBOSOMAL PROTEIN L30
    Polymer:45Type:polypeptide(L)Length:60
    Chains:x
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 2
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 3
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 4
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 5
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 6
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry Expression System: Escherichia coli bl21(de3)  
    Polymer: 7
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 8
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 9
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 10
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 11
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 12
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 13
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 14
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 15
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 16
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 17
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 18
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 19
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 20
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 21
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 22
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 23
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 24
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 25
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 26
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 27
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 28
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 29
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 30
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 31
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 32
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 33
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 34
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 35
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 36
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 37
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 38
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 39
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 40
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 41
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 42
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 43
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 44
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
    Polymer: 45
    Scientific Name: Escherichia coli Go to NCBI Taxonomy entry  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1DT9  eRF1 crystal structure 
    1GIX  crystal structure of 30S ribosome subunit 
    1GIY  crystal structure of 50S ribosome subunit 
    1GQE  RF2 crystal structure 
     
     
  •  
    Move Section Modified Residues Hide
    Identifier Name Formula Interaction View Links
    2MG 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE (parent: G)(type: rnaLinking) C11 H16 N5 O8 P 3D Ligand Explorer Link out to Ligand Expos:2MG Link out to SuperLigands:2MG Link out to SuperHapten:2MG 2D
    H2U 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE (parent: U)(type: rnaLinking) C9 H15 N2 O9 P 3D Ligand Explorer Link out to Ligand Expos:H2U Link out to SuperLigands:H2U Link out to SuperHapten:H2U 2D
    M2G N2-DIMETHYLGUANOSINE-5'-MONOPHOSPHATE (parent: G)(type: rnaLinking) C12 H18 N5 O8 P 3D Ligand Explorer Link out to Ligand Expos:M2G Link out to SuperLigands:M2G Link out to SuperHapten:M2G 2D
    OMC O2'-METHYLYCYTIDINE-5'-MONOPHOSPHATE (parent: C)(type: rnaLinking) C10 H16 N3 O8 P 3D Ligand Explorer Link out to Ligand Expos:OMC Link out to SuperLigands:OMC Link out to SuperHapten:OMC 2D
    OMG O2'-METHYLGUANOSINE-5'-MONOPHOSPHATE (parent: G)(type: rnaLinking) C11 H16 N5 O8 P 3D Ligand Explorer Link out to Ligand Expos:OMG Link out to SuperLigands:OMG Link out to SuperHapten:OMG 2D
    YG WYBUTOSINE (parent: G)(type: rnaLinking) C21 H29 N6 O12 P 3D Ligand Explorer Link out to Ligand Expos:YG Link out to SuperLigands:YG Link out to SuperHapten:YG 2D
    PSU PSEUDOURIDINE-5'-MONOPHOSPHATE (parent: U)(type: rnaLinking) C9 H13 N2 O9 P 3D Ligand Explorer Link out to Ligand Expos:PSU Link out to SuperLigands:PSU Link out to SuperHapten:PSU 2D
    5MC 5-METHYLCYTIDINE-5'-MONOPHOSPHATE (parent: C)(type: rnaLinking) C10 H16 N3 O8 P 3D Ligand Explorer Link out to Ligand Expos:5MC Link out to SuperLigands:5MC Link out to SuperHapten:5MC 2D
    7MG 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE (parent: G)(type: rnaLinking) C11 H18 N5 O8 P 3D Ligand Explorer Link out to Ligand Expos:7MG Link out to SuperLigands:7MG Link out to SuperHapten:7MG 2D
    5MU 5-METHYLURIDINE 5'-MONOPHOSPHATE (parent: U)(type: rnaLinking) C10 H15 N2 O9 P 3D Ligand Explorer Link out to Ligand Expos:5MU Link out to SuperLigands:5MU Link out to SuperHapten:5MU 2D
    1MA 6-HYDRO-1-METHYLADENOSINE-5'-MONOPHOSPHATE (parent: A)(type: rnaLinking) C11 H18 N5 O7 P 3D Ligand Explorer Link out to Ligand Expos:1MA Link out to SuperLigands:1MA Link out to SuperHapten:1MA 2D
     
     
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