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Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax
 
 
DOI:10.2210/pdb1im3/pdb
1IM3
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Viral Protein/immune System
    Structure Weight: 222815.16
     
    Molecule:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN
    Polymer:1Type:polypeptide(L)Length:275
    Chains:A, E, I, M
    Fragment:extracellular domain, heavy chain
    Molecule:beta-2-microglobulin
    Polymer:2Type:polypeptide(L)Length:100
    Chains:B, F, J, N
    Fragment:recombinant residues 1-99
    Molecule:Human T-cell lymphotropic virus type 1 Tax peptide
    Polymer:3Type:polypeptide(L)Length:9
    Chains:C, G, K, O
    Molecule:cytomegalovirus protein US2
    Polymer:4Type:polypeptide(L)Length:95
    Chains:D, H, L, P
    Fragment:recombinant ER-lumenal fragment
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens Go to NCBI Taxonomy entry Common Name: Human Expression System: Escherichia coli bl21(de3)  
    Polymer: 2
    Scientific Name: Homo sapiens Go to NCBI Taxonomy entry Common Name: Human Expression System: Escherichia coli bl21(de3)  
    Polymer: 3
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
    Polymer: 4
    Scientific Name: Human herpesvirus 5 Go to NCBI Taxonomy entry Common Name: Human cytomegalovirus Expression System: Escherichia coli bl21(de3)  
     
     
  •  
    Move Section Derived Data Hide
     
     
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Biological assembly 1 assigned by authors
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Gewurz, B.E.,   Gaudet, R.,   Tortorella, D.,   Wang, E.W.,   Ploegh, H.L.,   Wiley, D.C.

    Deposition:   2001-05-09
    Release:   2001-06-06
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 2.20
    R-Value: 0.206 (obs.)
    R-Free: 0.240
    Space Group: P 1
    Unit Cell:
      Length [Å] Angles [°]
    a = 95.48 α = 109.02 
    b = 96.70 β = 109.46 
    c = 99.54 γ = 107.93